41759-19-7

Basic information

• Product Name: 4-Methoxy-1-Methylpyridin-2(1H)-one
• Synonyms: 4-Methoxy-1-Methylpyridin-2(1H)-one;4-Methoxy-1-methyl-2(1H)-pyridinone
• CAS NO: 41759-19-7
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.15186
• Mol File: 41759-19-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 305.9°Cat760mmHg
• Flash Point: 138.8°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 0.000797mmHg at 25°C
• Refractive Index: 1.529
• PKA: -0.10±0.62(Predicted)
• CAS DataBase Reference: 4-Methoxy-1-Methylpyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-1-Methylpyridin-2(1H)-one(41759-19-7)
• EPA Substance Registry System: 4-Methoxy-1-Methylpyridin-2(1H)-one(41759-19-7)

Safety Data

• Hazardous Substances Data: 41759-19-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H9NO2/c1-8-4-3-6(10-2)5-7(8)9/h3-5H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 40357-87-7 1,2-dihydro-4-hydroxy-1-methyl-2-oxopyridine 
• 18677-43-5 2,4-dimethoxypyridine 
• 74-88-4 methyl iodide 
• 524-40-3 ricinin 
• 626-03-9 4-hydroxy-2-pyridone 
• 77-78-1 dimethyl sulfate 
• 1122-96-9 4-methoxypyridine N-oxide 
• 870854-86-7 3-Methoxy-3-methyl-2-benzenesulfonylpropenenitrile 
• 870854-88-9 4-methoxy-3-(phenylsulfonyl)pyridin-2(1H)-one 
• 52545-13-8 4-methoxypyridin-2(1H)-one 
• 870854-85-6 4-methoxy-1-methyl-3-(phenylsulfonyl)pyridin-2(1H)-one 

Downstream Products

• 110820-75-2 1,1,6,6-Tetraphenyl-hexa-2,4-diyne-1,6-diol; compound with 4-methoxy-1-methyl-1H-pyridin-2-one 
• 121463-29-4 1:1 complex of 4-methoxy-1-methylpyridone and (R,R)-(-)-1,6-bis(o-chlorophenyl)-1,6-diphenylhexa-2,4-diyne-1,6-diol 
• 139588-82-2 3-(α-hydroxybenzyl)-4-methoxy-1-methyl-2(1H)-pyridone 
• 121463-34-1 [(4R,5R)-5-(Hydroxy-diphenyl-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methanol; compound with 4-methoxy-1-methyl-1H-pyridin-2-one 
• 920490-72-8 3-bromo-4-methoxy-1-methylpyridin-2(1H)-one 
• 571168-97-3 4-(4-methoxy-1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylethynyl)-benzoic acid methyl ester 
• 112423-14-0 4-methoxy-1-methyl-3-phenylpyridin-2(1H)-one 
• 139588-83-3 3-benzoyl-4-methoxy-1-methyl-2(1H)-pyridone 
• 524-40-3 ricinin 
• 139588-97-9 4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1H)-one 
• 925901-05-9 4-methoxy-5-(4-methoxyphenyl)-1-methyl-3-(trimethylsilylethynyl)pyridin-2(1H)-one 
• 920490-89-7 3-iodo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1H)-one 
• 920490-79-5 3-bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1H)-one 
• 920490-71-7 3-bromo-5-iodo-4-methoxy-1-methylpyridin-2(1H)-one 

Relevant articles and documents

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FUROPYRIDINES AS BROMODOMAIN INHIBITORS

The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

Lithiation of 4-Methoxy-2-pyridones. Synthetic Entry to Tenellin and Funiculosin, and Related Natural 3,5-Disubstituted 4-Oxy-2-pyridones

Lithiation of 4-methoxy-2-pyridone with butyllithium at -78 deg C occurs at the C-3 position exclusively.Subsequent reactions with MeOD, MeI, CO2, benzaldehyde or (E)-but-2-enal then lead to the corresponding C-3-substituted derivatives. in a one-pot procedure, treatment of 1,2-dihydro-4-methoxy-1-methyl-2-oxopyridine-3-carboxylic acid with ammonia in the presence of a polyphosphate buffer at 80 deg C produced natural ricinine in 58percent overall yield.A convenient three-step synthesis of 5-aryl- and 5-alkyl-substituted 4-methoxy-2-pyridones is described.Lithiation of these substrates, followed by reaction with electrophiles, provided a convenient route to 3,5-disubstituted 4-oxy-2-pyridones, and a synthetic entry to natural products, e. g. tenellin and funiculosin, containing this structural feature.