1319068-99-9

Basic information

• Product Name: 8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
• Synonyms: 8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
• CAS NO: 1319068-99-9
• Molecular Weight: 244.683
• Mol File: 1319068-99-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine(1319068-99-9)
• EPA Substance Registry System: 8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine(1319068-99-9)

Safety Data

• Hazardous Substances Data: 1319068-99-9(Hazardous Substances Data)

Upstream product

• 1124383-00-1 N-(3-bromo-2-pyridinyl)-N’-carboethoxy-thiourea 
• 13534-99-1 2-Amino-3-bromopyridine 
• 1124382-72-4 8-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-ylamine 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 1329670-05-4 [8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-amine 

Relevant articles and documents

GAMMA SECRETASE MODULATORS

The invention relates to compounds of formula wherein R1, R1′, R2, R3, n, A, and hetaryl are defined herein or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

HETEROARYL SUBSTITUTED PIPERIDINES

The invention relates to compounds of formula where hetaryl I, hetaryl II, R1,R2,R3, R4, m, n, and o are as defined in the specification or to pharmaceutically active acid addition salts thereof. The compounds of formula I are modulators for amyloid beta and thus may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.