112462-87-0

Upstream product

• 112462-96-1 (R)-2-((S)-5,5-Dimethoxy-piperidin-2-yl)-1-phenyl-ethanol 
• 112462-99-4 (3R,6S)-6-((R)-2-Hydroxy-2-phenyl-ethyl)-piperidin-3-ol 
• 112462-94-9 (2R,3aS)-6,6-Dimethoxy-2-phenyl-hexahydro-isoxazolo[2,3-a]pyridine 
• 112462-92-7 (S)-6-((R)-2-Hydroxy-2-phenyl-ethyl)-piperidin-3-one 
• 112462-90-5 1-Ethyl-3,3-dimethoxy-piperidine 
• 100-42-5 styrene 
• 112462-99-4 (3S,6S)-6-((R)-2-Hydroxy-2-phenyl-ethyl)-piperidin-3-ol 
• 112462-91-6 3,3-Dimethoxy-piperidin-1-ol 
• 50-00-0 formaldehyd 
• 1578270-25-3 C₁₃H₁₉NO₂ 
• 1578270-24-2 (3S,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-tosylpiperidin-3-ol 
• 1578270-23-1 (S)-2-((2S,5S)-5-acetoxy-1-tosylpiperidin-2-yl)-1-phenylethyl 2-chloroacetate 
• 165674-68-0 Methyl (2S,5S)-5-hydroxy-2-(2-oxo-2-phenylethyl)piperidine-1-carboxylate 
• 153401-04-8 (2S,5R)-2-((S)-2-Acetoxy-2-phenyl-ethyl)-5-hydroxy-piperidine-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

A synthesis of 5-hydroxysedamine using hydroformylation

A synthesis of 5-hydroxysedamine, a Sedum alkaloid, has been completed using N,O-heterocycle chemistry to establish the aminoalcohol structure, hydroformylation to form the piperidine ring and diastereoselective dihydroxylation to introduce the 5-hydroxy group.

Asymmetric syntheses of (-)-epi-pseudoconhydrine and (-)-5-hydroxysedamine based on a cis-diastereoselective 1,4-asymmetric induction

The asymmetric syntheses of (-)-epi-pseudoconhydrine and (-)-5-hydroxysedamine are reported. The key to these syntheses is an unusual highly cis-diastereoselective 1,4-asymmetric induction in the α-amidoallylation of the new chiral building block 15.

Synthesis of β-hydroxypiperidine alkaloids by anodic oxidation of carbamates and hydroboration

The β-hydroxypiperidine alkaloids (±)-pseudoconhydrine, (±)-N-methylpseudoconhydrine, (-)-5-hydroxysedamine, and (+)-sedacryptine were synthesized. Successive functionalization of the piperidine ring via anodic methoxylation allowed the regio- and stereos

Synthesis of (+)- and (-)-Hydroxysedamine and (+)-N-Methylpseudoconhydrine from (S)-Glutamic Acid via Homochiral Acyliminium Ion

Efficient syntheses of (+)-N-methylpseudoconhydrine (5) and (-)-hydroxysedamine (10) are described starting from the readily available (2RS,5S)-Methyl 5-(tert-butyldimethylsilyloxy)-2-ethoxypiperidine-1-carboxylate (1) and proceeding via homochiral acylim

Hydroboration of Enecarbamates and the Synthesis of β-Hydroxypiperidine Alkaloids

The β-hydroxypiperidine alkaloids 5, 6 and 8 were diastereoselectively synthesized using hydroboration of enecarbamates 2b-c as a key step.

SEDUM ALKALOIDS. X. STRUCTURE AND SYNTHESIS OF NEW 3- AND 5-HYDROXYPIPERIDINE ALKALOIDS.

The structure and absolute configuration of (-)-3-hydroxynorallosedamine 1, (-)-3-hydroxyallosedamine 2 and (-)-5-hydroxysedamine 3, three new minor alklaloids isolated from Sedum acre, are reported.A nitrone-based synthesis of the new bases is described.