1125-39-9

Basic information

• Product Name: 1-methylhypoxanthine
• Synonyms: 1-methylhypoxanthine;1,7-Dihydro-1-methyl-6H-purin-6-one
• CAS NO: 1125-39-9
• Molecular Formula: C₆H₆N₄O
• Molecular Weight: 0
• Mol File: 1125-39-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 470°C at 760 mmHg
• Flash Point: 238.1°C
• Appearance: /
• Density: 1.6g/cm³
• Vapor Pressure: 5.24E-09mmHg at 25°C
• Refractive Index: 1.772
• CAS DataBase Reference: 1-methylhypoxanthine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylhypoxanthine(1125-39-9)
• EPA Substance Registry System: 1-methylhypoxanthine(1125-39-9)

Safety Data

• Hazardous Substances Data: 1125-39-9(Hazardous Substances Data)

Usage

Definition

ChEBI: A methylhypoxanthine that is hypoxanthine with the methyl group at position 1.

InChI:InChI=1/C6H6N4O/c1-10-3-9-5-4(6(10)11)7-2-8-5/h2-3H,1H3,(H,7,8)

Upstream product

• 2140-73-0 1-methylinosine 
• 118974-80-4 6-<(4-methoxybenzyl)(2-oxo-2-phenylethyl)amino>-5-nitro-4(3H)-pyrimidinone 
• 118974-82-6 9-(4-methoxybenzyl)hypoxanthine 7-N-oxide 
• 118974-81-5 hypoxanthine 7-N-oxide 
• 118974-84-8 7-methoxy-1-methylhypoxanthine 
• 82145-41-3 5-Formylamino-1H-imidazole-4-carboxylic acid methylamide 
• 87-42-3 6-chloro-7H-purine 
• 112088-77-4 6-chloro-7-[(4-methoxyphenyl)methyl]-7H-purine 
• 3181-38-2 O^2'_,O3'_,O5'-triacetyl-inosine 
• 64194-59-8 6-amino-5-formylamino-3-methyl-3H-pyrimidin-4-one 

Downstream Products

• 1006-22-0 1-methyl-1,7⁽⁹⁾-dihydro-purine-6-thione 

Relevant articles and documents

OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS

The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Purines. LI. Synthesis and biological activity of hypoxanthine 7-N-oxide and related compounds

A detailed account is given of the first chemical synthesis of hypoxanthine 7-N-oxide (5), which started from coupling of 6-chloro-5-nitro-4(3H)-pyrimidinone (7) with N-(4-methoxybenzyl)phenacylamine, generated in situ from the hydrochloride (8), and proceeded through cyclization of the resulting phenacylamino pyrimidinone (9) and removal of the 4-methoxybenzyl group. The results of catalytic hydrogenolysis, methylation followed by catalytic hydrogenolysis, and rearrangement under acidic conditions of 5 supported the correctness of the assigned structure. An ultraviolet spectroscopic approach suggested that the neutral species of 5 exists in H2O mainly as the N(7)-OH tautomer (21). In the in vitro bioassay of antileukemic activity against murine L5178Y cells, 5 was weakly cytotoxic, with IC50 of 100 μg/ml. It did not show any antimicrobial activity even at 1000 μg/ml. None of the 9-(4-methoxybenzyl) (11) and O-methyl (12, 13, and 14) derivatives was found to be antileukemic or antimicrobial.

Acyclic analogues of purine and imidazole nucleosides

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