2140-73-0

Basic information

• Product Name: Inosine, 1-methyl
• Synonyms: Inosine, 1-methyl;N1-Methylinosine;RNA-modified nucleoside m1I;WJNGQIYEQLPJMN-LEIICMHDSA-N
• CAS NO: 2140-73-0
• Molecular Formula: C₁₁H₁₄N₄O₅
• Molecular Weight: 282.25
• Mol File: 2140-73-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 211-212 °C
• Boiling Point: 695.3±65.0 °C(Predicted)
• Appearance: /
• Density: 1.88±0.1 g/cm3(Predicted)
• Refractive Index: 1.801
• PKA: 13.22±0.70(Predicted)
• CAS DataBase Reference: Inosine, 1-methyl(CAS DataBase Reference)
• NIST Chemistry Reference: Inosine, 1-methyl(2140-73-0)
• EPA Substance Registry System: Inosine, 1-methyl(2140-73-0)

Safety Data

• Hazardous Substances Data: 2140-73-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2140-73-0 differently. You can refer to the following data:
1. 1-Methyl-Inosine is a modified nucleoside which is present in higher concentrations in the urinary excretion of patients afflicted with breast cancer. It acts a a biomarker for diagnosis of the diseas e.
2. 1-Methyl-Inosine is a modified nucleoside which is present in higher concentrations in the urinary excretion of patients afflicted with breast cancer. It acts a a biomarker for diagnosis of the disease.

Definition

ChEBI: Inosine carrying a methyl substituent at position 1 on the hypoxanthine ring.

InChI:InChI=1/C11H16N4O5/c1-14-3-13-9-6(10(14)19)12-4-15(9)11-8(18)7(17)5(2-16)20-11/h4-5,7-8,11,16-19H,2-3H2,1H3/t5-,7-,8-,11-/m1/s1

Upstream product

• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 60-29-7 diethyl ether 
• 67-64-1 acetone 
• 3181-38-2 O^2'_,O3'_,O5'-triacetyl-inosine 
• 80-48-8 methyl p-toluene sulfonate 
• 58-63-9 Inosine 
• 684-93-5 1-methyl-1-nitrosourea 
• 18412-81-2 dodecyl-dimethylsulphonium iodide 
• 58-63-9 inosine 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 353-39-9 Trimethylsulfonium Fluoride 
• 1899-02-1 trimethylphenylammonium hydroxide 

Downstream Products

• 1125-39-9 1-Methylhypoxanthine 
• 661471-80-3 5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]inosine 
• 236752-17-3 5'-O-(4,4'-dimethoxytrityl)-1-methylinosine 

Relevant articles and documents

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth—Generation by Prebiotic Methylations and Carbamoylations

The RNA-world hypothesis assumes that life on Earth started with small RNA molecules that catalyzed their own formation. Vital to this hypothesis is the need for prebiotic routes towards RNA. Contemporary RNA, however, is not only constructed from the four canonical nucleobases (A, C, G, and U), it also contains many chemically modified (noncanonical) bases. A still open question is whether these noncanonical bases were formed in parallel to the canonical bases (chemical origin) or later, when life demanded higher functional diversity (biological origin). Here we show that isocyanates in combination with sodium nitrite establish methylating and carbamoylating reactivity compatible with early Earth conditions. These reactions lead to the formation of methylated and amino acid modified nucleosides that are still extant. Our data provide a plausible scenario for the chemical origin of certain noncanonical bases, which suggests that they are fossils of an early Earth.

The Synthesis of 2′-O-[(Triisopropylsilyl)oxy] methyl (TOM) Phosphoramidites of Methylated Ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for Use in Automated RNA Solid-Phase Synthesis

The straightforward synthesis of eight methylated ribonucleoside phosphoramidites is described. These building blocks allow for incorporation of the naturally occuring nucleosides 1-methylguanosine (m1G), N 2-methylguanosine (m2G), N2N 2-dimethylguanosine (m22G), 1-methylinosine (m1I), 3-methyluridine (m3U), N4- methylcytidine (m4C), N6-methyladenosine (m6A), and N6,N6-dimethyladenosine (m62A) into oligoribonucleotides by automated RNA solid-phase synthesis. In all cases, the ribose 2′-hydroxyl group of the building blocks is masked by the recently introduced [(triisopropylsilyl)oxy]methyl (TOM) group.

The Methylation of Ribonucleosides by Trimethyl Phosphate or Dimethyl Sulfate in the Presence of Boric Acid

Uridine, inosine, adenosine, and thymidine were methylated selectively at the base moieties by the use of trimethyl phosphate or dimethyl sulfate in the presence of boric acid.A suppressing effect of boric acid on the methylation of the ribose-hydroxyl groups was discussed briefly.