112586-65-9

Usage

Type of compound

Ketone derivative

Presence of functional groups

Hydroxyl group, Phenyl ring

Properties

Aromatic and aliphatic properties

Usage in organic synthesis

Commonly used as a reagent in chemical reactions

Usage in perfumery and flavoring

Known for its sweet, fruity odor and used in the production of perfumes and flavorings

Pharmaceutical applications

Potential building block for various drugs and medicinal compounds

Hazards and precautions

Can be hazardous if not properly used and stored

Upstream product

• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 67-64-1 acetone 

Downstream Products

• 120384-06-7 (1R*,2R*)-2,3-Dimethyl-1-phenylbutan-1,3-diol 

Relevant academic research and scientific papers

The chromium Reformatsky reaction: Access to adjacent quarternary centers

α-Bromo ketones, -esters and -nitriles react with chromium dichloride and ketones in a Barbier-type reaction to yield the kinetic crossed aldol products with one or two new quarternary centers. The reaction does not require special activation of the reage

Reaction of α-Halogeno Ketones with Carbonyl Compounds Promoted by CeI3, CeCl3-NaI,or CeCl3-SnCl2

Reaction of α-halogeno ketones with aldehydes in the presence of CeI3 in tetrahydrofuran is found to give α,β-unsaturated ketones in excellent yields under mild conditions.In contrast, treatment of α-halogeno ketones and carbonyl compounds with CeCl3-NaI or CeCl3-SnCl2 affords β-hydroxy ketones in good yields.It is assumed that these reactions proceed via cerium enolates.The combined reagents, however, cannot be applied to a Reformatsky-type reaction.Regiospecific and aldehyde chemoselective aldol synthesis are also described.