1125861-68-8

Basic information

• Product Name: 4-(((3-chlorophenyl)(phenyl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one
• CAS NO: 1125861-68-8
• Molecular Weight: 396.824
• Mol File: 1125861-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(((3-chlorophenyl)(phenyl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(((3-chlorophenyl)(phenyl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one(1125861-68-8)
• EPA Substance Registry System: 4-(((3-chlorophenyl)(phenyl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one(1125861-68-8)

Safety Data

• Hazardous Substances Data: 1125861-68-8(Hazardous Substances Data)

Upstream product

• 108-42-9 3-chloro-aniline 
• 4519-40-8 2,3-difluoroanilline 
• 953070-72-9 4-(bromomethyl)-7,8-difluoroquinolin-2(1H)-one 
• 101-17-7 3-chlorodiphenylamine 
• 953071-01-7 4-bromo-N-(2,3-difluorophenyl)-3-oxobutanamide 
• 1125702-46-6 N-(2,3-difluorophenyl)-3-oxobutanamide 

Relevant articles and documents

Heteroaromatic-aminomethyl quinolones: Potent and selective iNOS inhibitors

The overproduction of nitric oxide during the biological response to inflammation by the nitric oxide synthase (NOS) enzymes have been implicated in the pathology of many diseases. By removal of the amide core from uHTS-derived quinolone 4, a new series highly potent heteroaromatic-aminomethyl quinolone iNOS inhibitors 8 were identified. SAR studies led to identification of piperazine 22 and pyrimidine 32, both of which reduced plasma nitrates following oral dosing in a mouse lipopolysaccharide challenge assay.