1126-56-3

Basic information

• Product Name: N-cyclohexylpropanamide
• Synonyms: N-cyclohexylpropanamide;N-Cyclohexylpropionamide
• CAS NO: 1126-56-3
• Molecular Formula: C₉H₁₇NO
• Molecular Weight: 155.2374
• Mol File: 1126-56-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 304.6°Cat760mmHg
• Flash Point: 177.2°C
• Appearance: /
• Density: 0.94g/cm³
• Vapor Pressure: 0.000866mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: N-cyclohexylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexylpropanamide(1126-56-3)
• EPA Substance Registry System: N-cyclohexylpropanamide(1126-56-3)

Safety Data

• Hazardous Substances Data: 1126-56-3(Hazardous Substances Data)

Usage

General Description

N-cyclohexylpropanamide, also known as cyclohexylpropionamide, is a chemical compound with the molecular formula C9H17NO. It is a white crystalline solid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. N-cyclohexylpropanamide is also used as a crosslinking agent in the production of polyurethanes, and as a corrosion inhibitor in metalworking fluids. It is considered to be of low toxicity, with no known adverse effects on human health and the environment. However, it should be handled and stored with care due to its potential irritation to the skin, eyes, and respiratory system. Overall, N-cyclohexylpropanamide is a versatile chemical with various industrial applications.

InChI:InChI=1/C9H17NO/c1-2-9(11)10-8-6-4-3-5-7-8/h8H,2-7H2,1H3,(H,10,11)

Upstream product

• 79-03-8 propionyl chloride 
• 108-91-8 cyclohexylamine 
• 802294-64-0 propionic acid 
• 1122-56-1 cyclohexylcarboxamide 
• 105-37-3 Ethyl propionate 
• 78-38-6 ethylphosphonic acid diethyl ester 
• 3173-53-3 Cyclohexyl isocyanate 
• 598-22-1 propanoyl bromide 
• 107-12-0 propiononitrile 
• 108-93-0 cyclohexanol 
• 620-71-3 N-(phenyl)-2-methylacetamide 
• 286-20-4 cyclohexane-1,2-epoxide 
• 286-18-0 7-azabicyclo[4.1.0]heptane 
• 153789-15-2 7-propanoyl-7-azabicyclo<4.1.0>heptane 

Downstream Products

• 1124-53-4 N-cyclohexylacetamide 
• 3592-81-2 N-propylcyclohexylamine 
• 26672-58-2 1-(4-dimethylaminophenyl)propan-1-one 
• 1007-35-8 Propionsaeure-cyclohexylimidchlorid 
• 46165-46-2 1-cyclohexyl-5-ethyl-1H-tetrazole 
• 4671-03-8 3-ethyl-4-cyclohexyl-4H-[1,2,4]triazole 

Relevant articles and documents

Catalytic hydrogenation of amides to amines under mild conditions

Under (not so much) pressure: A general method for the hydrogenation of tertiary and secondary amides to amines with excellent selectivity using a bimetallic Pd-Re catalyst has been developed. The reaction proceeds under low pressure and comparatively low temperature. This method provides organic chemists with a simple and reliable tool for the synthesis of amines. Copyright

Safe and efficient ritter reactions in flow

Efficient mixing, temperature control and small environmental exposures allow reactions carried out in microfluidic de-vices to perform superior to their batch-type counterparts in conventional flasks. The Ritter reaction has been optimised for flow conditions leading to short reaction times and higher yields and also is more feasible with regards to safety, productivity and tolerance towards substrate functionalities.

Synthesis of dendritic oligo(aryl sulfone)s as supports for synthesis

A short, divergent route to G1 oligo(aryl sulfone)s and a G 2 oligo(aryl sulfone) dendrimer using nucleophilic aromatic substitution reactions is described. A range of tetrasubstituted pentasulfones are proposed for applications as homogeneous supports for synthesis. Key to achieving selectivity in the syntheses is the activation of leaving groups by sulfide to sulfone oxidation. Preparation of the G2 oligo(aryl sulfone) is low-yielding due to competition from SET processes that are interesting from a mechanistic point of view. The utility of the supports is exemplified with a four step synthesis of a dipeptide and by 'react and release' synthesis of amides.