87307-96-8

Upstream product

• 87307-84-4 ethyl 3-<4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl>propanoate 
• 87307-93-5 ethyl 3-<4-<2-(ethoxymethoxy)-3-methoxyphenyl>pyridin-3-yl>propenoate 
• 87307-88-8 ethyl 3-<4-<2-(ethoxymethoxy)-3-methoxyphenyl>pyridin-3-yl>propanoate 
• 87307-83-3 ethyl 3-<4-<3-methoxy-2-(phenylmethoxy)phenyl>pyridin-3-yl>propenoate 
• 87307-91-3 ethyl 1,4-dihydro-4-<2-(ethoxymethoxy)-3-methoxyphenyl>-3-(3-ethoxy-3-oxopropenyl)pyridine-1-carboxylate 
• 87307-90-2 3-(2-Ethoxycarbonyl-ethyl)-4-(2-ethoxymethoxy-3-methoxy-phenyl)-4H-pyridine-1-carboxylic acid ethyl ester 
• 87307-92-4 1-Ethoxycarbonyl-3-((E)-2-ethoxycarbonyl-vinyl)-pyridinium; chloride 
• 87307-89-9 1-Ethoxycarbonyl-3-(2-ethoxycarbonyl-ethyl)-pyridinium; chloride 
• 59607-99-7 ethyl (E)-3-(pyridin-3-yl)acrylate 
• 87307-82-2 4-<3-methoxy-2-(phenylmethoxy)phenyl>pyridine-3-carboxaldehyde 
• 64107-54-6 3-pyridin-3-yl-propionic acid ethyl ester 
• 87307-95-7 4-(2-hydroxy-3-methoxyphenyl)-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide 
• 105-36-2 ethyl bromoacetate 
• 1126-74-5 3-(pyridin-3-yl)acrylic acid 

Relevant academic research and scientific papers

Synthesis and Opioid Activity of 7-Oxygenated 2,3,4,4a,5,6,7,7a-Octahydro-1H-benzofuroisoquinolin-9-ols

3-(Cyclopropylmethyl)-9-hydroxy-7-oxo-2,3,4,4aα,5,6,7,7aα-octahydro-1H-benzofuroisoquinoline (4b) containing the ACNO ring system of morphine and a 7-keto function on ring C has been synthesized and found to possess potent PQW (ED50 = 0.15 mg/kg sc

Synthesis of 3-Methyl-5,6-dihydro-3H-benzofuroisoquinolin-7(7aH)-ones

The coupling of 2-(alkoxymethoxy)phenylcopper derivatives with the salt of ethyl chloroformate and ethyl 3-(pyridin-3-yl)propenoate was found to be an efficient method for the preparation of 4-(2-hydroxyphenyl)pyridines 13 substituted at C-3 with a propanoate side chain.N-Methylation and O-alkylation with ethyl bromoacetate gave salts 3 which when treated with base underwent an intramolecular enolate addition to the pyridinium nucleus to produce spiro 4.Prolonged base treatment of 4 yielded ethyl 3-methyl-7-hydroxy-5,7a-dihydro-3H-benzofuroisoquinoline-6-carboxylates 5 by a Dieckmann reaction.Reduction of 5 led to predominately trans-3-methylhexahydro-1H-benzofuroisoquinolin-7(7aH)-ones, while reduction of 4 and then Dieckmann cyclization yielded mainly the cis isomers.