1126367-88-1

Basic information

• Product Name: 5-bromo-4-chloro-2-methylaniline
• Synonyms: 5-bromo-4-chloro-2-methylaniline;BenzenaMine, 5-broMo-4-chloro-2-Methyl-;5-bromo-4-chloro-2-methylbenzenamine;5-Bromo-4-chloro-2-methyl-phenylamine
• CAS NO: 1126367-88-1
• Molecular Formula: C₇H₇BrClN
• Molecular Weight: 220.49418
• EINECS: 604-604-1
• Mol File: 1126367-88-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-bromo-4-chloro-2-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-4-chloro-2-methylaniline(1126367-88-1)
• EPA Substance Registry System: 5-bromo-4-chloro-2-methylaniline(1126367-88-1)

Safety Data

• Hazardous Substances Data: 1126367-88-1(Hazardous Substances Data)

Usage

General Description

5-bromo-4-chloro-2-methylaniline, also known as BCM or 4-bromo-2-chloro-5-methylaniline, is a chemical compound with the molecular formula C7H7BrClN. It is a substituted aniline, which is a type of aromatic amine. 5-bromo-4-chloro-2-methylaniline is commonly used as an intermediate in the synthesis of various pharmaceuticals, dyes, and agrochemicals. It is also used as a building block in organic synthesis and as a reagent in chemical reactions. 5-bromo-4-chloro-2-methylaniline is a pale yellow solid at room temperature and is soluble in organic solvents. It is important to handle this compound with caution as it may be harmful if ingested or inhaled and can cause skin and eye irritation upon contact.

Upstream product

• 6627-51-6 1-bromo-2-chloro-4-methylbenzene 
• 1126367-34-7 1-bromo-2-chloro-4-methyl-5-nitrobenzene 

Downstream Products

• 1126369-57-0 N-(5-bromo-4-chloro-2-methylphenyl)-4-(pyridin-2-ylmethoxy)benzamide 
• 1126368-31-7 N-[4-chloro-2-methyl-5-(1-methyl-1H-imidazol-2-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide 
• 1126368-35-1 N-[4-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide 
• 1126366-38-8 N-[4-chloro-2-methyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide 
• 1126368-33-9 N-[4-chloro-5-(1H-imidazol-2-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide 
• 1126367-36-9 N-(4-chloro-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-(pyridin-2-ylmethoxy)benzamide 

Relevant articles and documents

N-HETEROARYL INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

COMPOUNDS

Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

HETEROCYCLIC AMIDES USEFUL FOR THE TREATMENT OF CANCER AND PSORIASIS

The present disclosure relates to heterocyclic amide compounds, which are useful for inhibiting the Hedgehog pathway, and their use in treating a disease or medical condition mediated alone or in part by Hedgehog pathway inhibition. Also disclosed are methods for manufacture of these compounds, pharmaceutical compositions including these compounds, and use of these compounds in the manufacture of medicaments for treating such diseases and medical conditions in a subject. Formula (IA) with the provisio that either R2or R3 is (Z).