1126444-46-9

Upstream product

• 128353-08-2 1-(indolizin-1-yl)ethan-1-one 
• 98-09-9 benzenesulfonyl chloride 
• 80-17-1 benzenesufonyl hydrazide 
• 873-55-2 sodium benzenesulfonate 
• 100-42-5 styrene 
• 6302-02-9 2-acetonylpyridine 
• 536-74-3 phenylacetylene 
• 1126444-25-4 1-(3-chloroindolizin-1-yl)ethan-1-one 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Iodine-Catalyzed Radical Oxidative Annulation for the Construction of Dihydrofurans and Indolizines

Through iodine catalysis, the direct oxidative coupling/annulation of β-keto esters or 2-pyridinyl-β-esters with alkenes was achieved. This reaction procedure provides a simple and selective way for the synthesis of dihydrofurans and indolizines in one st

Iodine-Mediated Oxidative Cyclization of 2-(Pyridin-2-yl)acetate Derivatives with Alkynes: Condition-Controlled Selective Synthesis of Multisubstituted Indolizines

An iodine-mediated oxidative cyclization reaction between 2-(pyridin-2-yl)acetate derivatives and different alkynes has been developed, which provides regioselective and chemoselective syntheses of multiply substituted indolizines under modified reaction

Palladium-catalyzed C-3 desulfitative arylation of indolizines with sodium arylsulfinates and arylsulfonyl hydrazides

Derivatized indolizines were efficiently prepared by direct C-3 arylation of indolizines using sodium arylsulfinates and arylsulfonyl hydrazides. Pd-catalyzed desulfitative C-3 arylation with sodium arylsulfinates was achieved with the assistance of peroxides, and the catalytic efficiency was promoted by N-containing ligands. Arylsulfonyl hydrazides were also successfully applied in Pd-catalyzed desulfitative C-3 arylation with indolizines, and the side homocoupling reactions can be restrained in the component solvent under milder conditions. Various derivatives were synthesized in good yields by both methods, offering expedient protocols for the synthesis of C-3 functionalized indolizine molecules.

Desulfitative palladium-catalyzed direct C-3 arylation of indolizines with arylsulfonyl chlorides

An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1-methyl-2-pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C-3 arylation of indolizines. An efficient Pd-catalyzed desulfitative approach to C-3 arylation of indolizine derivatives has been developed, the protocol using readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation proceeds in a mixed solvent of NMP and DME using simple triphenylphosphine a ligand, and provides a new method for the C-3 arylation of indolizines.

Tuning radical reactivity using iodine in oxidative C(sp3)-H/C(sp)-H cross-coupling: An easy way toward the synthesis of furans and indolizines

Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C-I bond formation for co

Synthesis of 3-Haloindolizines by copper(ii) halide mediated direct functionalization of indolizines

3-Haloindolizines were synthesized via Cu(II) halide mediated halogenation of indolizines. This C-H direct functionalization process occurred under mild conditions giving 3-haloindolizines in moderate to excellent yields, and the products obtained were tested under the Suzuki-Miyaura reaction providing 3-arylindolizines in high yields.