1126476-68-3Relevant academic research and scientific papers
Synthesis of novel 3D-rich α-amino acid-derived 3-pyrazolidinones
Glava?, Jaka,Dahmann, Georg,Po?gan, Franc,Ri?ko, Sebastijan,?tefane, Bogdan,Svete, Jurij,Gro?elj, Uro?
, p. 715 - 726 (2018/01/17)
Synthetic approaches towards novel 3-pyrazolidinone derivatives functionalized at positions N(1) and/or C(5) were studied. 5-Aminoalkyl-3-pyrazolidinones were prepared in four steps from N-protected glycines via Masamune-Claisen homologation, reduction, O
Resolution of 5-oxo-1-phenylpyrazolidine-3-carboxylic acid and synthesis of novel enantiopure amide derivatives
Melgar-Fernandez, Roberto,Gonzalez-Olvera, Rodrigo,Vargas-Caporali, Jorge,Perez-Isidoro, Rosendo,Juaristi, Eusebio
scheme or table, p. 55 - 75 (2010/09/03)
The synthesis is reported of (±)-5-oxo-1-phenylpyrazolidine-3- carboxylic acid, (±)-3, via nucleophilic addition of phenylhydrazine to dimethyl maleate, followed by cyclization of the resulting hydrazine-diester. The resolution of (±)-3 was achieved via diastereomeric salts employing (R)- and (S)-a-methylbenzylamine as resolving agent. Preferential crystallization of the like (R,R)- and (S,S)- salts allowed the isolation of the desired enantiomerically pure (R)- and (S)- target compounds in up to 87-89 % of the theoretical yield. An X-ray structure of the (S,S)- salt allowed secure assignment of its relative configuration, and thus unequivocal assignment of the absolute configuration in the enantiomeric heterocycles.
Optical resolution of 5-oxo-1-phenyl-pyrazolidine-3-carboxylic acid as a new organocatalyst for organic reactions
Tzeng, Zheng-Hao,Yang, Shuen-Wen,Liu, Pang-Min,Chen, Kwun-Min
experimental part, p. 626 - 631 (2009/05/07)
Optical resolution of racemic 5-oxo-1-phenyl-pyrazolidine-3-carboxylic acid 2 with L-amino acid methyl ester via the diastereomers formation was investigated. Treatment of racemic 5-oxo-1-phenylpyrazolidine-3-carboxylic acid 2 with L-valine methyl ester g
