1126642-78-1

Basic information

• Product Name: 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide
• Synonyms: 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide
• CAS NO: 1126642-78-1
• Molecular Weight: 297.36
• Mol File: 1126642-78-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide(1126642-78-1)
• EPA Substance Registry System: 3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide(1126642-78-1)

Safety Data

• Hazardous Substances Data: 1126642-78-1(Hazardous Substances Data)

Upstream product

• 1415910-56-3 (1H-imidazol-1-yl)(3,5,6-trimethylpyrazin-2-yl)methanone 
• 54015-04-2 1-(4-tolyl)guanidine 
• 186534-01-0 3,5,6-trimethylpyrazine-2-carboxylic acid 
• 75907-74-3 2-Pyrazinemethanol,3,5,6-trimethyl 
• 97730-69-3 p-tolylguanidine carbonate 
• 79074-43-4 (3,5,6-trimethylpyrazin-2-yl)methyl acetate 
• 22978-83-2 2,3,5,6-tetramethylpyrazine mono N-oxide 
• 1124-11-4 Tetramethylpyrazine 

Relevant articles and documents

Ligustrazine derivatives. Part 6: Design, synthesis and evaluation of novel ligustrazinyl acylguanidine derivatives as potential cardiovascular agents

A series of novel Ligustrazinyl acylguanidines was designed, synthesized and evaluated for their protective effect on injured vascular endothelial cell (ECV-304). The preliminary results demonstrated that some compounds possessed more potent activities than that of Ligustrazine in stimulating replication of the injured endothelial cell. Among the active compounds, compounds 8b, 8f and 8l displayed remarkable antioxidative activity with low EC50 values of 0.097, 0.059 and 0.094 mM, respectively. Structure-activity relationships were briefly discussed.