1127213-37-9

Upstream product

• 4467-06-5 2-(4-methylphenyl)pyridine 
• 538-56-7 cinnamic acid anhydride 
• 102-92-1 cinnamoyl chloride 
• 100-42-5 styrene 

Relevant academic research and scientific papers

Method for carrying out selective mono-alkenylation and di-alkenylation on aromatic compound by taking pyridine as guide group based on hydrocarbon activation at room temperature

The invention discloses a method for carrying out selective mono-alkenylation and di-alkenylation on an aromatic compound by taking pyridine as a guide group based on hydrocarbon activation at room temperature. According to the method, the selective mono-

The C-H activated controlled mono- And di-olefination of arenes in ionic liquids at room temperature

In this study, controlled mono and di-olefination of arenes was first realized at room temperature via the C-H bond activation in ionic liquids, probably due to the positive effects of ionic liquids. It is an energy-saving routes in industrial production without the need for heating equipment. Different catalysts were screened, and it was found that [Ru(p-cymene)Cl2]2 generated mono-olefinated products predominantly while [Cp?RhCl2]2 selectively gave di-olefinated products. These catalysts ([BMIM]NTf2 and [BMIM]PF6) as green and recyclable reaction media are highly efficient under mild conditions. This reaction process can avoid any volatile and environmentally toxic organic solvents, and is much safer without the need for pressure-tight equipment. A wide substrate scope with good yields and satisfactory selectivity was achieved. The reactions can be scaled up to gram-scale. Furthermore, an expensive rhodium/ruthenium catalytic system was recycled for at least 6 times with consistently high catalytic activity, which was economical and environmental friendly from an industrial point of view. According to the mechanistic study, the C-H bond cleavage was probably achieved via the concerted metalation-deprotonation. This technique can be applied in the synthesis of various valuable unsaturated aromatic compounds and shows a great potential for industrial production.

Rhodium-catalyzed direct alkenylation and arylation of arene C-H bonds via decarbonylation of cinnamoyl chlorides, cinnamic anhydrides, and poly(aroyl) chlorides

Efficient regioselective direct alkenylation of benzo[h]quinoline was realized with cinnamoyl chlorides as the coupling partners via decarbonylation of the chlorides and C-H bond activation by means of [Rh(CO)2Cl] 2 as the catalyst i

Efficient Rh(I)-Catalyzed direct arylation and alkenylation of arene C-H bonds via decarbonylation of benzoic and cinnamic anhydrides

Efficient rhodium(I)-catalyzed regioselective direct arylation and alkenylation of aromatic C-H bonds has been realized with aromatic carboxylic and cinnamic anhydrides as the coupling partners via decarbonylation and C-H activation under phosphine-free c