1127499-22-2

Basic information

• Product Name: 4-bromo-1-butylpyridin-2(1H)-one
• Synonyms: 4-bromo-1-butylpyridin-2(1H)-one
• CAS NO: 1127499-22-2
• Molecular Weight: 230.104
• Mol File: 1127499-22-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromo-1-butylpyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1-butylpyridin-2(1H)-one(1127499-22-2)
• EPA Substance Registry System: 4-bromo-1-butylpyridin-2(1H)-one(1127499-22-2)

Safety Data

• Hazardous Substances Data: 1127499-22-2(Hazardous Substances Data)

Upstream product

• 109-65-9 1-bromo-butane 
• 36953-37-4 4-bromo-2(1H)-pyridinone 

Downstream Products

• 1127499-59-5 1-butyl-4-(4-phenyl-1-piperidyl)pyridin-2-one 
• 1127499-92-6 1'-butyl-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2-one 
• 1213766-64-3 (2aα,3α,3aα)-1-butyl-4-[6-(2,5-dichloro-phenoxymethyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-1H-pyridin-2-one 
• 1213766-66-5 (2aα,3α,3aα)-1-butyl-3-chloro-4-[6-(2,5-dichloro-phenoxymethyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-1H-pyridin-2-one 
• 1127498-03-6 1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2(1H)-one 

Relevant articles and documents

Synthesis and evaluation of thiomannosides, potent and orally active FimH inhibitors

FimH is a type I fimbrial lectin located at the tip of type-1 pili of Gram-negative uropathogenic Escherichia coli (UPEC) guiding its ability to adhere and infect urothelial cells. Accordingly, blocking FimH with small molecule inhibitor is considered as a promising new therapeutic alternative to treat urinary tract infections caused by UPEC. Herein, we report that compounds having the S-glycosidic bond (thiomannosides) had improved metabolic stability and plasma exposures when dosed orally. Especially compound 5h showed the potential to inhibit biofilm formation and also to disrupt the preformed biofilm. And compound 5h showed prophylactic effect in UTI model in mice.