112768-15-7Relevant academic research and scientific papers
C–H-Alkenylation of Arenes in a One-Pot VNS – Julia-Kocienski Reaction
Loska, Rafa?
, p. 6649 - 6656 (2018)
A one-pot reaction sequence is reported that enables direct introduction of alkenyl substituents into C–H positions of electron-poor aromatic compounds under transition metal free conditions. The process incorporates vicarious nucleophilic substitution of hydrogen with carbanion of benzotriazolyl chloromethyl sulfone, followed by Julia-Kocienski olefination with aliphatic or aromatic aldehydes or trifluoromethyl ketones. The resulting nitrostyrene derivatives are usually formed with very high E/Z selectivity.
Synthesis of Coumarins by Nucleophilic Denitrocyclization Reaction
Oda, Noriichi,Yoshida, Yukio,Nagai, Shin-ichi,Ueda, Taisei,Sakakibara, Jinsaku
, p. 1796 - 1802 (2007/10/02)
2-propanedioic acids(2a-c) were denitrocyclized to coumarins (3a-c) by heating in quinoline in the presence of copper powder. 2-(4-Methoxiphenyl)-3-(2-nitrophenyl)-(Z)-2-propenoic acids (6a,b,d,e) were also similarly denitrocycli
