112775-38-9

Upstream product

• 112775-37-8 Toluene-4-sulfonic acid (R)-10-benzyloxy-undec-7-ynyl ester 
• 16695-31-1 1-(2-Tetrahydropyranyloxy)-7-octyne 
• 110-53-2 1-Bromopentane 
• 20739-58-6 2-octyn-1-ol 
• 871-91-0 oct-7-yn-1-ol 
• 112775-34-5 (R)-11-(Tetrahydro-pyran-2-yloxy)-undec-4-yn-2-ol 
• 112775-35-6 2-((R)-10-Benzyloxy-undec-7-ynyloxy)-tetrahydro-pyran 
• 112775-36-7 (R)-10-Benzyloxy-undec-7-yn-1-ol 

Downstream Products

• 112775-39-0 ((R)-10-Benzyloxy-undec-7-ynyl)-triphenyl-phosphonium; bromide 
• 112775-40-3 {(2R,3S)-3-[(4R,5S)-5-((E)-(R)-11-Benzyloxy-dodec-1-en-8-ynyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-oxiranylmethoxy}-tert-butyl-dimethyl-silane 

Relevant academic research and scientific papers

STEREOCONTROLLED TOTAL SYNTHESIS OF THE MACROCYCLIC LACTONE (-)-ASPICILIN

The essential features of the enantiocontrolled total synthesis of (-)-aspicilin are the strategic use of the photochemical rearrangement of α,β-epoxy diazomethyl ketones to 4-hydroxyalkenoates (Scheme 1) and the stereochemical control of the Sharpless epoxidation, α,ο functionalization of an alkynol using potassium 3-aminopropylamine (KAPA) as acetylene zipper, coupling between C7 and C8 by means of a Wittig reaction and lactonization by using 2,6-dichlorobenzoyl chloride.