1127889-57-9Relevant articles and documents
N-heterocyclic Carbene-Cu-Catalyzed Enantioselective Conjugate Additions with Alkenylboronic Esters as Nucleophiles
Chong, Qinglei,Yue, Zhenting,Zhang, Shuoqing,Ji, Chonglei,Cheng, Fengchang,Zhang, Haiyan,Hong, Xin,Meng, Fanke
, p. 5693 - 5698 (2017)
Catalytic enantioselective conjugate additions with easily accessible alkenylboronic acid pinacol esters as nucleophiles promoted by chiral copper complexes of N-heterocyclic carbenes are presented. These processes constitute an unprecedented instance of conjugate additions of a variety of functionalized alkenyl groups and afford desired products that are otherwise difficult to access in up to 98% yield and 99.5:0.5 enantiomeric ratio. The origins of ligand-controlled enantioselectivity are elucidated with density functional theory (DFT) calculations.
Iridium-catalyzed enantioselective allylic alkylation using chiral phosphoramidite ligand bearing an amide moiety
Onodera, Gen,Watabe, Keijiro,Matsubara, Masaki,Oda, Kazuhiro,Kezuka, Satoko,Takeuchi, Ryo
scheme or table, p. 2725 - 2732 (2009/11/30)
New chiral phosphoramidites with an amide moiety were used for iridium-catalyzed asymmetric allylic alkylation reactions. The best results were obtained with a ligand bearing an oxazolidinone moiety. The reaction of cinnamyl acetate with diethyl sodiomalonate without the use of lithium chloride gave the branched product with 94% ee.
