15115-52-3

Basic information

• Product Name: 4-BROMO-1-PHENYL-1H-PYRAZOLE
• Synonyms: 4-BROMO-1-PHENYL-1H-PYRAZOLE;4-Bromo-1-phenyl-1H-pyrazole 98%;4-bromo-1-phenylpyrazole
• CAS NO: 15115-52-3
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.07
• Product Categories: Azoles;blocks;Bromides
• Mol File: 15115-52-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 78-79 °C
• Boiling Point: 296.238 °C at 760 mmHg
• Flash Point: 132.96 °C
• Appearance: /
• Density: 1.503 g/cm³
• Vapor Pressure: 0.00256mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: 2-8°C
• PKA: -1.34±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-1-PHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1-PHENYL-1H-PYRAZOLE(15115-52-3)
• EPA Substance Registry System: 4-BROMO-1-PHENYL-1H-PYRAZOLE(15115-52-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 15115-52-3(Hazardous Substances Data)

Usage

Uses

4-Bromo-1-phenylpyrazole is used to prepare canagliflozin aryl C-glucoside with thiophene ring as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.

InChI:InChI=1/C9H7BrN2/c10-8-6-11-12(7-8)9-4-2-1-3-5-9/h1-7H

Upstream product

• 20638-31-7 4-bromo-1-phenyl-1H-pyrazole-3,5-dicarboxylic acid 
• 59360-06-4 α-bromo-β-anilineacrolein 
• 64-19-7 acetic acid 
• 100-63-0 phenylhydrazine 
• 19263-02-6 2-bromo-3-hydroxypropenal 
• 64-17-5 ethanol 
• 56-23-5 tetrachloromethane 
• 1134-50-5 4-carboxy-1-phenylpyrazole 
• 7726-95-6 bromine 
• 2075-45-8 4-bromo-1H-pyrazole 
• 71-43-2 benzene 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 54605-72-0 1-phenyl-1H-pyrazole-4-carbaldehyde 

Downstream Products

• 51039-46-4 3,4,5-tribromo-1-phenyl-1H-pyrazole 
• 15754-94-6 4-bromo-1-(4-bromophenyl)pyrazole 
• 1126-00-7 1-phenylpyrazole 
• 18830-03-0 1,1'-diphenyl-1H,1'H-4,4'-bipyrazole 
• 95881-82-6 6,6′-dimethoxy-3,3′-bipyridine 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 65480-21-9 1-Phenylphenanthro[9,10-d]pyrazole 
• 1128-53-6 1-phenyl-1H-pyrazol-4-amine 

Relevant articles and documents

A fast and efficient bromination of isoxazoles and pyrazoles by microwave irradiation

A fast and efficient method has been developed for the bromination of isoxazoles and pyrazoles using microwave irradiation. In this method, N-bromosuccinimide was used in different acid solvents according to the reactivity of the substrates to give mono-b

Unveiling Potent Photooxidation Behavior of Catalytic Photoreductants

We describe a photocatalytic system that reveals latent photooxidant behavior from one of the most reducing conventional photoredox catalysts, N-phenylphenothiazine (PTH). This aerobic photochemical reaction engages difficult to oxidize feedstocks, such as benzene, in C(sp2)-N coupling reactions through direct oxidation. Mechanistic studies are consistent with activation of PTH via photooxidation and with Lewis acid cocatalysts scavenging inhibitors inextricably formed in this process.

A quick, mild and efficient bromination using a CFBSA/KBr system

Bromination is a fundamental transformation in organic chemistry and brominated compounds as building blocks are of paramount importance in organic synthesis. In our study, we have developed an efficient method of bromination by using a CFBSA/KBr system at room temperature in a short reaction time. Notably, this approach has been proven to be applicable to a range of substrates including 1,3-diketones and β-keto esters, phenols, aromatic amines and heteroarenes with good to excellent yields.