1128-74-1

Basic information

• Product Name: 7-FLUORO-2-METHYLQUINOLINE
• Synonyms: 2-METHYL-7-FLUOROQUINOLINE;7-FLUORO-2-METHYLQUINOLINE 98+%;7-Fluoro-2-methylpyridine;2-Methyl-7-flruoroquinoline;7-FLUOROQUINALDINE;7-FLUORO-2-METHYLQUINOLINE
• CAS NO: 1128-74-1
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.18
• Product Categories: blocks;FluoroCompounds;Heterocycles;Quinolines, Quinazolines and derivatives;Quinoline&Isoquinoline;Alkylquinolines;Haloquinolines;Quinolines;Building Blocks;Heterocyclic Building Blocks
• Mol File: 1128-74-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 47-51 °C(lit.)
• Boiling Point: 120 °C / 15mmHg
• Flash Point: 195 °F
• Appearance: /
• Density: 1.379g/cm³
• Vapor Pressure: 0.0985mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4?+-.0.50(Predicted)
• CAS DataBase Reference: 7-FLUORO-2-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-2-METHYLQUINOLINE(1128-74-1)
• EPA Substance Registry System: 7-FLUORO-2-METHYLQUINOLINE(1128-74-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1128-74-1(Hazardous Substances Data)

Usage

General Description

7-Fluoro-2-methylquinoline is a chemical compound with the molecular formula C10H8FN. It is a quinoline derivative with a fluorine atom at the 7th position and a methyl group at the 2nd position of the quinoline ring. 7-FLUORO-2-METHYLQUINOLINE is often used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its unique structure and reactivity. It has been studied for its potential as an antifungal and antibacterial agent, as well as its ability to inhibit certain enzymes. 7-Fluoro-2-methylquinoline is also being investigated for its use in material science applications, particularly in the development of fluorescent dyes and polymers.

InChI:InChI=1/C10H5F4N/c11-7-3-1-6-2-4-9(10(12,13)14)15-8(6)5-7/h1-5H

Upstream product

• 66023-21-0 2-methyl-6-(trifluoromethyl)-quinoline 
• 372-19-0 meta-fluoroaniline 
• 109-92-2 ethyl vinyl ether 
• 560085-09-8 7-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 123-73-9 trans-Crotonaldehyde 

Downstream Products

• 560085-09-8 7-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 168082-74-4 CGP 57698 
• 168083-08-7 3-(7-fluoro-2-quinolinylmethoxy)aniline 
• 91-63-4 2-methylquinoline 

Relevant articles and documents

Deracemization of Phenyl-Substituted 2-Methyl-1,2,3,4-Tetrahydroquinolines by a Recombinant Monoamine Oxidase from Pseudomonas monteilii ZMU-T01

A monoamine oxidase (MAO5) from Pseudomonas monteilii ZMU-T01 was first heterologously expressed in Escherichia coli BL21(DE3) and then used as a biocatalyst for the deracemization of racemic 2-methyl-1,2,3,4-tetrahdroquinoline derivatives to yield the unreacted R enantiomer with up to >99 % ee. Sequence alignment revealed that MAO5 shared 14.7 % identity toward the well-studied monoamine oxidase (MAO-N).

Synthesis and Characterization of Iron-Nitrogen-Doped Graphene/Core-Shell Catalysts: Efficient Oxidative Dehydrogenation of N-Heterocycles

An important goal for nanocatalysis is the development of flexible and efficient methods for preparing active and stable core-shell catalysts. In this respect, we present the synthesis and characterization of iron oxides surrounded by nitrogen-doped-graphene shells immobilized on carbon support (labeled FeOx@NGr-C). Active catalytic materials are obtained in a simple, scalable and two-step method via pyrolysis of iron acetate and phenanthroline and subsequent selective leaching. The optimized FeOx@NGr-C catalyst showed high activity in oxidative dehydrogenations of several N-heterocycles. The utility of this benign methodology is demonstrated by the synthesis of pharmaceutically relevant quinolines. In addition, mechanistic studies prove that the reaction progresses via superoxide radical anions (·O2-).

Novel N-acylated heterocycles

Described are compositions comprising a muscarinic receptor antagonist and an N-acylated heterocycle derivative having affinity for serotonergic receptors, and enantiomers, diastereoisomers, N-oxides, polymorphs, solvates and pharmaceutically acceptable salts thereof. The combination of a muscarinic receptor antagonist and an N-acylated heterocycle, or an enantiomer, diastereoisomer, N-oxide, polymorph, solvate or pharmaceutically acceptable salt thereof, is useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT1A receptors.