1128-74-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
7-Fluoro-2-methylquinoline is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, leveraging its unique structure and reactivity to create novel compounds with potential therapeutic and pesticidal properties.
Used in Antifungal and Antibacterial Applications:
7-Fluoro-2-methylquinoline is studied for its potential as an antifungal and antibacterial agent, with its ability to inhibit the growth of various pathogenic microorganisms, making it a promising candidate for the development of new antimicrobial drugs.
Used in Enzyme Inhibition:
7-Fluoro-2-methylquinoline has been investigated for its ability to inhibit certain enzymes, which could be useful in the treatment of various diseases and conditions by modulating enzyme activity.
Used in Material Science:
7-Fluoro-2-methylquinoline is being explored for its use in material science applications, particularly in the development of fluorescent dyes and polymers, due to its unique chemical properties and potential for fluorescence-based applications.

InChI:InChI=1/C10H5F4N/c11-7-3-1-6-2-4-9(10(12,13)14)15-8(6)5-7/h1-5H

Upstream product

• 66023-21-0 2-methyl-6-(trifluoromethyl)-quinoline 
• 372-19-0 meta-fluoroaniline 
• 560085-09-8 7-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 109-92-2 ethyl vinyl ether 
• 123-73-9 trans-Crotonaldehyde 

Downstream Products

• 560085-09-8 7-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 91-63-4 2-methylquinoline 

Relevant academic research and scientific papers

Deracemization of Phenyl-Substituted 2-Methyl-1,2,3,4-Tetrahydroquinolines by a Recombinant Monoamine Oxidase from Pseudomonas monteilii ZMU-T01

A monoamine oxidase (MAO5) from Pseudomonas monteilii ZMU-T01 was first heterologously expressed in Escherichia coli BL21(DE3) and then used as a biocatalyst for the deracemization of racemic 2-methyl-1,2,3,4-tetrahdroquinoline derivatives to yield the unreacted R enantiomer with up to >99 % ee. Sequence alignment revealed that MAO5 shared 14.7 % identity toward the well-studied monoamine oxidase (MAO-N).

Metal-Free Dehydrogenation of N-Heterocycles by Ternary h-BCN Nanosheets with Visible Light

An efficient metal-free catalytic system has been developed based on hexagonal boron carbon nitride (h-BCN) nanosheets for the dehydrogenation of N-heterocycles with visible light; hydrogen gas is released in the process, and thus no proton acceptor is needed. This acceptorless dehydrogenation of hydroquinolines, hydroisoquinolines, and indolines to the corresponding aromatic N-heterocycles occurred in excellent yield under visible-light irradiation at ambient temperature. With h-BCN as the photocatalyst and water as the solvent, this environmentally benign protocol shows broad substitution tolerance and high efficiency.

Synthesis and Characterization of Iron-Nitrogen-Doped Graphene/Core-Shell Catalysts: Efficient Oxidative Dehydrogenation of N-Heterocycles

An important goal for nanocatalysis is the development of flexible and efficient methods for preparing active and stable core-shell catalysts. In this respect, we present the synthesis and characterization of iron oxides surrounded by nitrogen-doped-graphene shells immobilized on carbon support (labeled FeOx@NGr-C). Active catalytic materials are obtained in a simple, scalable and two-step method via pyrolysis of iron acetate and phenanthroline and subsequent selective leaching. The optimized FeOx@NGr-C catalyst showed high activity in oxidative dehydrogenations of several N-heterocycles. The utility of this benign methodology is demonstrated by the synthesis of pharmaceutically relevant quinolines. In addition, mechanistic studies prove that the reaction progresses via superoxide radical anions (·O2-).

Assembly of substituted 2-alkylquinolines by a sequential palladium-catalyzed Ci-N and Ci-C bond formation

Diversity: A range of substituted 2-alkylquinolines can be prepared in a general and efficient synthetic approach that employs mild reaction conditions (see scheme). The synthesis is based on a sequential palladium-catalyzed Ci-N and Ci-C bond formation, followed by palladium-catalyzed aromatization, and results in the formation of the desired compounds in one step. Copyright

Novel N-acylated heterocycles

Described are compositions comprising a muscarinic receptor antagonist and an N-acylated heterocycle derivative having affinity for serotonergic receptors, and enantiomers, diastereoisomers, N-oxides, polymorphs, solvates and pharmaceutically acceptable salts thereof. The combination of a muscarinic receptor antagonist and an N-acylated heterocycle, or an enantiomer, diastereoisomer, N-oxide, polymorph, solvate or pharmaceutically acceptable salt thereof, is useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT1A receptors.