1129-62-0

Basic information

• Product Name: butan-2-one phenylhydrazone
• Synonyms: butan-2-one phenylhydrazone;2-Butanone,phenylhydrazone;2-Butanone, 2-phenylhydrazone;Einecs 214-452-3
• CAS NO: 1129-62-0
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23156
• EINECS: 214-452-3
• Mol File: 1129-62-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 245.1°Cat760mmHg
• Flash Point: 102°C
• Appearance: /
• Density: 0.93g/cm³
• Vapor Pressure: 0.029mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: butan-2-one phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: butan-2-one phenylhydrazone(1129-62-0)
• EPA Substance Registry System: butan-2-one phenylhydrazone(1129-62-0)

Safety Data

• Hazardous Substances Data: 1129-62-0(Hazardous Substances Data)

Usage

Description

Butan-2-one phenylhydrazone, also known as dimethyl phenyl hydrazone, is a chemical compound derived from the ketone butan-2-one and phenylhydrazine. It is commonly used as a reagent in organic chemistry reactions and is known for its role in the synthesis of pharmaceuticals and other organic compounds. butan-2-one phenylhydrazone forms yellow crystals and is soluble in organic solvents, making it versatile for various laboratory applications. However, it is important to handle butan-2-one phenylhydrazone with caution due to potential risks to human health and the environment if not used properly.

Uses

Used in Organic Chemistry:
Butan-2-one phenylhydrazone is used as a reagent in organic chemistry for its ability to participate in various chemical reactions. Its solubility in organic solvents and formation of yellow crystals make it a valuable compound for laboratory work.
Used in Detection of Carbonyl Compounds:
Butan-2-one phenylhydrazone is used as a qualitative test for detecting the presence of carbonyl compounds. Its reaction with these compounds provides a visual indication of their presence, which is crucial for analytical chemistry and research purposes.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, butan-2-one phenylhydrazone is used as a key intermediate in the synthesis of various organic compounds and pharmaceuticals. Its versatility and reactivity contribute to the development of new drugs and medicinal compounds.
Used in Research and Development:
Butan-2-one phenylhydrazone is utilized in research and development for the exploration of new chemical reactions and the creation of novel organic compounds. Its properties make it a valuable tool for scientists working in the field of organic chemistry and related disciplines.

InChI:InChI=1/C10H14N2/c1-3-9(2)11-12-10-7-5-4-6-8-10/h4-8,12H,3H2,1-2H3/b11-9+

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 78-93-3 butanone 
• 100-63-0 phenylhydrazine 
• 85216-98-4 ((E)-1-Methyl-propenyl)-phenyl-diazene 
• 52187-73-2 N,N'-diacetyl-N-phenyl-N'-(1-methyl-1-propenyl)hydrazine 
• 624-46-4 butan-2-one semicarbazone 
• 108-88-3 toluene 
• 563-80-4 3-methyl-butan-2-one 

Downstream Products

• 116436-00-1 3,4-dimethyl-1-phenyl-1H-pyrazole 
• 100875-90-9 N,N'-diacetyl-N-sec-butyl-N'-phenyl-hydrazine 
• 18440-34-1 1-Methyl-1-phenylazo-propyl-isocyanat 
• 5877-05-4 butan-2-one-(2-phenyl semicarbazone) 
• 33966-50-6 SEC-BUTYLAMINE 
• 626-23-3 Di-sec-butylamin 
• 62-53-3 aniline 
• 96-29-7 ethyl methyl ketone oxime 
• 78-93-3 butanone 
• 91-55-4 2,3-dimethylindole 
• 940-45-4 sec-butylphenyldiimide 
• 118863-87-9 4,5-dimethyl-2-phenyl-2H-1,2,3-diazaphosphole 
• 18108-38-8 5-ethyl-2-phenyl-2H-1,2,3-diazaphosphole 
• 3484-18-2 2-ethylindole 

Relevant articles and documents

Vilsmeier formylation of hydrazones and semicarbazones derived from alkyl, benzyl, and cycloalkyl methyl ketones

Formylation of ten accessible phenylhydrazones and semicarbazones derived from alkyl, benzyl, and cycloalkyl methyl ketones with the complex of POCl 3 with dimethylformamide was studied. Depending on the electronic and steric structure of the substrates, the reaction yields 1-phenyl- or 1-unsubstituted 3,4-dialkyl-, 3-alkyl-4-aryl-, or 3-alkyl-4-formylpyrazoles. These compounds can be readily oxidized into the corresponding carboxylic acids. 2005 Pleiades Publishing, Inc.

Shaken, not stirred: a schools test for aldehydes and ketones

A schools test for aldehydes and ketones in water at room temperature using test tubes has been developed in this laboratory using either phenylhydrazine hydrochloride or phenylhydrazine hydrochloride with NaOAc . 3H2O. The role of one equivalent of a strong or weak acid which catalyses the reaction is discussed.

Phenylsilane as an effective desulfinylation reagent

The reduction using phenylsilane in a KOH-catalyzed system was applied successfully to the conversion of sulfinyl-substituted cyclopropylcarboxylates into the corresponding alcohols. The presence of sulfinyl substituents in the α-position to the carboxylate group caused a desulfinylation product formation with full regio- and stereoselectivity, instead of a carbonyl group reduction. Investigations performed on different α-sulfinylcarbonyl compounds revealed that phenylsilane treatment constitutes a regiospecific method for the desulfinylation of a-sulfinylesters; for corresponding ketones the reaction course depends on the character of the carbonyl group.

Fast hydrazone reactants: Electronic and acid/base effects strongly influence rate at biological pH

Kinetics studies with structurally varied aldehydes and ketones in aqueous buffer at pH 7.4 reveal that carbonyl compounds with neighboring acid/base groups form hydrazones at accelerated rates. Similarly, tests of a hydrazine with a neighboring carboxylic acid group show that it also reacts at an accelerated rate. Rate constants for the fastest carbonyl/hydrazine combinations are 2-20 M-1 s-1, which is faster than recent strain-promoted cycloaddition reactions.