112916-68-4

Upstream product

• 112916-81-1 (5Z)-7-<3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>hept-2-endo-yl>heptenoic acid methyl ester 
• 2825-86-7 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indene 
• 43000-60-8 2-endo-(carboxymethyl)-3-endo-carboxybicyclo<2.2.1>heptane 
• 112917-32-5 2-endo-(carbomethoxymethyl)-3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>heptane 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 112918-01-1 2-endo-(carbomethoxymethyl)-3-exo-carboxybicyclo<2.2.1>heptane 
• 112918-01-1 2-endo-(carbomethoxymethyl)-3-endo-carboxybicyclo<2.2.1>heptane 
• 112916-81-1 (5Z)-7-<3-endo-<(phenylsulfonyl)amino>bicyclo<2.2.1>hept-2-endo-yl>heptenoic acid methyl ester 
• 98-09-9 benzenesulfonyl chloride 
• 125109-77-5 (1S,2R,6S,7R)-3-Benzenesulfonyl-3-aza-tricyclo[5.2.1.0^2,6]decan-4-ol 
• 112916-81-1 (5Z)-7-<3-exo-<(phenylsulfonyl)amino>bicyclo<2.2.1>hept-2-exo-yl>heptenoic acid methyl ester 
• 128299-81-0 (3'R,4'R,5'S,6'S)-5'-(Formylmethyl)-4'-benzenesulfonamidobicyclo<2.2.1>heptane 
• 39968-97-3 (4-carboxybutylene)triphenylphosphorane 
• 128217-41-4 (4S)-3-((E)-5'-(Benzyloxy)-2'-penetnoyl)-4-(phenylmethyl)-2-oxazolidinone 

Relevant academic research and scientific papers

Synthesis and in vitro activity of stereoisomers of a novel thromboxane receptor antagonist, (±)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo[2.2.1]hept-2-exo-yl ]heptenoic acid

Three stereoisomers of S-145 (1) with variations at the side-chain junctions were synthesized. Endo-cis-isomer 10 and N-exo-trans isomer 18 were obtained via the common intermediate 5 having an endo-fused ring structure. Exo-cis isomer 28 was prepared via

Asymetric Diels-Alder Reactions with γ-Functionalized α,β-Unsaturated Chiral N-Acyloxazolidinones: Synthesis of (+)-S-145

An extension of the asymmetric Diels-Alder cycloaddition with chiral γ-substituted, α,β-unsaturated imides is described.The application of these results to the synthesis of the potent TxA2 receptor antagonist (+)-S-145 was successfully achieved in a practical manner.