112916-68-4Relevant academic research and scientific papers
Asymetric Diels-Alder Reactions with γ-Functionalized α,β-Unsaturated Chiral N-Acyloxazolidinones: Synthesis of (+)-S-145
Martinelli, Michael J.
, p. 5065 - 5073 (2007/10/02)
An extension of the asymmetric Diels-Alder cycloaddition with chiral γ-substituted, α,β-unsaturated imides is described.The application of these results to the synthesis of the potent TxA2 receptor antagonist (+)-S-145 was successfully achieved in a practical manner.
Synthesis and in vitro activity of stereoisomers of a novel thromboxane receptor antagonist, (±)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo[2.2.1]hept-2-exo-yl ]heptenoic acid
Ohtani,Narisada
, p. 1027 - 1031 (2007/10/02)
Three stereoisomers of S-145 (1) with variations at the side-chain junctions were synthesized. Endo-cis-isomer 10 and N-exo-trans isomer 18 were obtained via the common intermediate 5 having an endo-fused ring structure. Exo-cis isomer 28 was prepared via
