112970-73-7Relevant articles and documents
PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
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Page/Page column 50-51, (2018/09/21)
The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases
Palladium-Catalyzed Coupling Reactions of (α-Ethoxyvinyl)trimethylstannane with Vinyl and Aryl Triflates
Kwon, Hyok Boong,McKee, Blain H.,Stille, J. K.
, p. 3114 - 3118 (2007/10/02)
The palladium-catalyzed cross-coupling reaction of vinyl triflates and halides with (α-ethoxyvinyl)trimethylstannane gives high yields of 2-ethoxy 1,3-dienes, which can be hydrolyzed to the corresponding α,β-unsaturated ketones.Aryl triflates undergo an analogous coupling reaction, providing a facile method for replacing the hydroxyl group of a phenol by an acyl group.The use of (α-ethoxyvinyl)trimethylstannane in palladium-catalyzed carbonylative coupling gives rise to vinyl and aryl α-ethoxyvinyl ketones and indirectly to the corresponding α-diketones (which result from their hydrolysis) and glyoxylates (which result from their ozonolysis).