112970-73-7Relevant academic research and scientific papers
PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
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Page/Page column 50-51, (2018/09/21)
The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases
PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS
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Page/Page column 75, (2017/03/21)
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
Palladium-Catalyzed Coupling Reactions of (α-Ethoxyvinyl)trimethylstannane with Vinyl and Aryl Triflates
Kwon, Hyok Boong,McKee, Blain H.,Stille, J. K.
, p. 3114 - 3118 (2007/10/02)
The palladium-catalyzed cross-coupling reaction of vinyl triflates and halides with (α-ethoxyvinyl)trimethylstannane gives high yields of 2-ethoxy 1,3-dienes, which can be hydrolyzed to the corresponding α,β-unsaturated ketones.Aryl triflates undergo an analogous coupling reaction, providing a facile method for replacing the hydroxyl group of a phenol by an acyl group.The use of (α-ethoxyvinyl)trimethylstannane in palladium-catalyzed carbonylative coupling gives rise to vinyl and aryl α-ethoxyvinyl ketones and indirectly to the corresponding α-diketones (which result from their hydrolysis) and glyoxylates (which result from their ozonolysis).
Palladium-Catalyzed Coupling of 2-Bromoanilines with Vinylstannanes. A Regiocontrolled Synthesis of Substituted Indoles
Krolski, Michael E.,Renaldo, Alfred F.,Rudisill, Duane E.,Stille, J. K.
, p. 1170 - 1176 (2007/10/02)
The palladium-catalyzed cross-coupling reaction of aryl halides and triflates with vinylstannane reagents has been used to produce a variety of substituted indoles.The mild reaction conditions and selectivity inherent in the coupling reaction have been utilized to produce regiochemically pure 4-, 5-, and 6-substituted indoles.
