113016-89-0

Upstream product

• 6318-64-5 1-(3-amino-4-methoxyphenyl)ethan-1-one 
• 6609-56-9 2-methoxy-benzonitrile 
• 75-36-5 acetyl chloride 
• 35310-75-9 3-bromo-4-methoxyacetophenone 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 79324-77-9 1‐(3‐iodo‐4‐methoxyphenyl)ethan‐1‐one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 188725-99-7 3-Cyano-4-(trifluoromethoxy)benzaldehyde 
• 6277-38-9 1-(4-methoxy-3-nitrophenyl)ethanone 

Downstream Products

• 531-99-7 5-acetyl-2-methoxybenzaldehyde 
• 39055-82-8 5-acetyl-2-hydroxybenzonitrile 

Relevant academic research and scientific papers

Synthesis of 3-bromo-5-(2-ethylimidazo[1, 2-a]pyridine-3-carbonyl)-2-hydroxybenzonitrile

The invention discloses a synthetic method of 3-bromo-5-(2-ethylimidazo[1,2-a]pyridine-3-carbonyl)-2-hydroxybenzonitrile, particularly relates to a synthetic method of a compound shown as a formula (III), and particularly relates to a step A or a step B;

An investigation of structure‐activity relationships of azolylacryloyl derivatives yielded potent and long‐acting hemoglobin modulators for reversing erythrocyte sickling

Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia‐induced HbS polymerization and the subsequent erythrocyte sickling have for s

Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution

Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.

URAT1 inhibitor and its application

The invention discloses a URAT1 inhibitor compound and its application of the compound. The URAT1 inhibitor compound is the compound or its pharmaceutically acceptable salt shown in structure of Formula (I). The experiment shows that the compound provided

COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT

Provided are a compound as represented in formula (I), a pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and uses thereof. The compound as represented in formula (I) and the pharmaceutically acceptable salts thereof are used in the preparation of medicines for the treatment or prevention of hyperuricemia or gout by means of uric acid excretion.

URAT1 inhibitor for promoting uric acid excretion

The invention belongs to the field of medicinal chemistry, and in particular relates to a URT1 inhibitor for promoting uric acid excretion, which is a compound represented by the structure of the formula (I) or a pharmaceutically acceptable salt thereof. Experiments show that the compound provided by the invention has excellent inhibitory effect to hURAT1 transport uric acid in HEK293 transfectedcells and has a good application prospect in treatment of hyperuricemia or gout. The formula (I) is shown in the description.

Substituted benzylaminopiperidine compounds

The invention provides a substituted benzylaminopiperidine compounds that are useful in the treatment of gastrointestinal disorders; central nervous system (CNS) disorders; inflammatory disease; emesis; urinary incontinence; pain; migraine; sunburn; diseases, disorders and adverse conditions caused byHeliobacter pylori;or angiogenesis, especially CNS disorders in a mammalian subject, especially in humans.

SUBSTITUENT EFFECTS IN AROMATIC PHOTOCHEMISTRY: UV IRRADIATION OF 3,4-DIMETHOXYBENZONITRILE AND 3,4-DIMETHOXYACETOPHENONE IN THE PRESENCE OF INORGANIC ANIONS

Ultraviolet photolysis of 3,4-dimethoxybenzonitrile (Ia) and 3,4-dimethoxyacetophenone (IIa) in the presence of the hydroxide or cyanide anions leads to nucleophilic displacement of either the para or the meta methoxy substituent.The ratio of isomeric photoproducts is dependent upon the nature of the nucleophile.Photoreactions with the OH(-) anion leads exclusively to the substitution at C-3.On the other hand, both isomers are formed when acetophenone IIa is irradiated in the presence of CN(-), with the C-3/C-4 ratio ranging from 1:2 to 1:6 in dependence on the nucleophile concentration.These difference between the OH(-) and CN(-) anion are related to the results of a fluorescence quenching study which has revealed that only the observed for the quenching of the second excited state of Ia by the cyanide anion.This indicates several distinct quenching modes, in relation to the concentration dependence of regioselectivity.The activating power of -H, -CN, -COCH3, and -NO2 substituents, as measured by relative quantum yields of disappearance for 3,4-dimethoxy-R-substituted benzenes, is 1 : 2.5 : 5 : 580 and 1 : 1.5 : 6 : 1000 in their photoreactions with OH(-) and CN(-) anions, respectively.