79324-77-9

Usage

Chemical Properties

Yellow powder

InChI:InChI=1/C9H9IO2/c1-6(11)7-3-4-9(12-2)8(10)5-7/h3-5H,1-2H3

Upstream product

• 6318-64-5 1-(3-amino-4-methoxyphenyl)ethan-1-one 
• 529-28-2 4-iodoanisol 
• 75-36-5 acetyl chloride 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 6277-38-9 1-(4-methoxy-3-nitrophenyl)ethanone 

Downstream Products

• 68507-19-7 3-iodo-4-methoxybenzoic acid 
• 1240519-86-1 1-(4-methoxy-3-(phenylethynyl)phenyl)ethanone 
• 113016-89-0 5‐acetyl‐2‐methoxybenzonitrile 
• 1431944-46-5 3-acetyl-6-methoxy-2-methylbenzonitrile 

Relevant academic research and scientific papers

Synthesis of 3-bromo-5-(2-ethylimidazo[1, 2-a]pyridine-3-carbonyl)-2-hydroxybenzonitrile

The invention discloses a synthetic method of 3-bromo-5-(2-ethylimidazo[1,2-a]pyridine-3-carbonyl)-2-hydroxybenzonitrile, particularly relates to a synthetic method of a compound shown as a formula (III), and particularly relates to a step A or a step B;

HETEROCYCLIC COMPOUND, PREPARATION METHOD AND USE THEREOF IN MEDICINE

Provided are a heterocyclic compound, a preparation method and the use thereof in medicine, and particularly involved are a heterocyclic compound for preventing and/or treating hypemricemia and gout, a preparation method and the use thereof in medicine. I

An investigation of structure‐activity relationships of azolylacryloyl derivatives yielded potent and long‐acting hemoglobin modulators for reversing erythrocyte sickling

Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia‐induced HbS polymerization and the subsequent erythrocyte sickling have for s

URAT1 inhibitor and its application

The invention discloses a URAT1 inhibitor compound and its application of the compound. The URAT1 inhibitor compound is the compound or its pharmaceutically acceptable salt shown in structure of Formula (I). The experiment shows that the compound provided

COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT

Provided are a compound as represented in formula (I), a pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and uses thereof. The compound as represented in formula (I) and the pharmaceutically acceptable salts thereof are used in the preparation of medicines for the treatment or prevention of hyperuricemia or gout by means of uric acid excretion.

URAT1 inhibitor for promoting uric acid excretion

The invention belongs to the field of medicinal chemistry, and in particular relates to a URT1 inhibitor for promoting uric acid excretion, which is a compound represented by the structure of the formula (I) or a pharmaceutically acceptable salt thereof. Experiments show that the compound provided by the invention has excellent inhibitory effect to hURAT1 transport uric acid in HEK293 transfectedcells and has a good application prospect in treatment of hyperuricemia or gout. The formula (I) is shown in the description.

Gold(I)-catalyzed iodination of arenes

A wide variety of electron-rich arenes were efficiently converted into the corresponding iodinated compounds via a gold(I)-catalyzed reaction under mild conditions. Georg Thieme Verlag Stuttgart. New York.

Effect of water on the functionalization of substituted anisoles with iodine in the presence of F-TEDA-BF4 or hydrogen peroxide

Water was found to be a convenient reaction medium for functionalization of substituted anisoles using iodine in the presence of Selectfluor F-TEDA-BF 4 or hydrogen peroxide as mediators and oxidizers. Two types of functionalization were observ

Solvent directed electrophilic iodination and phenylselenenylation of activated alkyl aryl ketones

A mixture of molecular iodine and phenyliodine(III) bis(trifluoroacetate) (BTI) in CH3CN (or CH3OH) iodinates the aromatic ring of some activated alkyl aryl ketones. A different outcome results if PhSeSePh is used instead of I2

Room temperature regioselective iodination of aromatic ethers mediated by Selectfluor(TM) reagent F-TEDA-BF4

Monosubstituted phenyl ethers were regioselectively iodinated with a mixture of iodine and F-TEDA in acetonitrile at room temperature at the para position, while 1-methoxy-4-substituted benzene derivatives were converted to 2-iodo products in high yield.