1130489-30-3Relevant academic research and scientific papers
A metal-free three-component reaction for the regioselective synthesis of 1,4,5-trisubstituted 1,2,3-triazoles
Thomas, Joice,John, Jubi,Parekh, Nikita,Dehaen, Wim
, p. 10155 - 10159 (2015/03/31)
A metal-free three-component reaction to synthesize 1,4,5-trisubstituted 1,2,3-triazoles from readily available building blocks,such as aldehydes,nitroalkanes,and organic azides,is described. The process is enabled by an organocatalyzed Knoevenagel condensation of the formyl group with the nitro compound,which is followed by the 1,3-dipolar cycloaddition of the azide to the activated alkene. The reaction features an excellent substrate scope,and the products are obtained with high yield and regioselectivity. This method can be utilized for the synthesis of fused triazole heterocycles and materials with several triazole moieties.
Discovery of chemoselective and biocompatible reactions using a high-throughput immunoassay screening
Kolodych, Sergii,Rasolofonjatovo, Evelia,Chaumontet, Manon,Nevers, Marie-Claire,Creminon, Christophe,Taran, Frederic
supporting information, p. 12056 - 12060 (2013/12/04)
An immunoassay-based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper-catalyzed reaction that generates pyrazoles from sydnone and alkyne reagents. Copyright
A cycloaddition route to novel triazole boronic esters
Huang, Jianhui,MacDonald, Simon J. F.,Harrity, Joseph P. A.
supporting information; experimental part, p. 436 - 438 (2009/05/06)
The [3 + 2] cycloaddition of alkynylboronates and azides provides a direct route to novel triazole boronic esters, the regioselectivity of this process and functionalisation of the heterocycle products is described. The Royal Society of Chemistry.
