113071-97-9

Basic information

• Product Name: Benzothiazole, 6-chloro-2-(chloromethyl)- (9CI)
• Synonyms: Benzothiazole, 6-chloro-2-(chloromethyl)- (9CI);2-Chloromethyl-6-chlorobenzothiazole;6-Chloro-2-(chloromethyl)benzo[d]thiazole, 97%
• CAS NO: 113071-97-9
• Molecular Formula: C₈H₅Cl₂NS
• Molecular Weight: 218.103
• Product Categories: BENZOTHIAZOLE
• Mol File: 113071-97-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzothiazole, 6-chloro-2-(chloromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 6-chloro-2-(chloromethyl)- (9CI)(113071-97-9)
• EPA Substance Registry System: Benzothiazole, 6-chloro-2-(chloromethyl)- (9CI)(113071-97-9)

Safety Data

• Hazardous Substances Data: 113071-97-9(Hazardous Substances Data)

Upstream product

• 23474-98-8 2-amino-5-chlorobenzenethiol 
• 51076-95-0 2-chloro-1,1,1-triethoxyethane 

Downstream Products

• 50739-39-4 2-(bromomethyl)-6-chloro-1,3-benzothiazole 

Relevant articles and documents

Highly selective aldose reductase inhibitors. II. Optimization of the aryl part of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids

Accumulation of intracellular sorbitol, the product of glucose reduction catalyzed by aldose reductase (AR) [EC 1.1.1.21], is thought to be the main culprit in the development of diabetic complications. A series of 3- arylalkyl-2,4,5-trioxoimidazolidine-1-acetic acids was prepared and tested for inhibitory activities towards AR and aldehyde reductase (ALR) [EC 1.1.1.2]. These derivatives showed strong inhibitory activity against AR without markedly inhibiting ALR. In particular, the compounds with 3- nitrophenyl, 4-chloro-3-nitrophenyl, and chloro-substituted benzothiazolyl groups as the aryl part showed powerful AR-inhibitory activity. The chloro- substituted benzothiazolyl compound showed an AR selectivity of more than 5000 fold.