113118-24-4

Basic information

• Product Name: acetic acid 2-acetoxy-4-hydroxymethyl-phenyl ester
• Synonyms: acetic acid 2-acetoxy-4-hydroxymethyl-phenyl ester
• CAS NO: 113118-24-4
• Molecular Weight: 224.213
• Mol File: 113118-24-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: acetic acid 2-acetoxy-4-hydroxymethyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid 2-acetoxy-4-hydroxymethyl-phenyl ester(113118-24-4)
• EPA Substance Registry System: acetic acid 2-acetoxy-4-hydroxymethyl-phenyl ester(113118-24-4)

Safety Data

• Hazardous Substances Data: 113118-24-4(Hazardous Substances Data)

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 120-57-0 piperonal 
• 67727-64-4 3,4-diacetoxybenzaldehyde 

Downstream Products

• 3897-89-0 4-(hydroxymethyl)benzene-1,2-diol 
• 223920-46-5 C₄₃H₅₆N₂O₁₂⁽²⁺⁾*2Br^(1-) 
• 124254-92-8 4-(bromomethyl)-1,2-phenylene diacetate 

Relevant articles and documents

N- and C-terminal modifications of negamycin

Negamycin 1 is a bactericidal antibiotic with activity against Gram-negative bacteria, and served as a template in an antibiotic discovery program. An orthogonally protected β-amino acid derivative 3a was synthesized and used in parallel synthesis of negamycin derivatives on solid support. This advanced intermediate was also used for N- and C-terminal modifications using solution-phase methodologies. The N-terminal modifications have resulted in the identification of active analogues, whereas the C-terminal modifications resulted in complete loss of antibacterial activity. The N-methyl negamycin analogue, 19a, inhibits protein synthesis (IC50=2.3 μM), has antibacterial activity (Escherichia coli, MIC=16 μg/mL), and is efficacious in an E. coli murine septicemia model (ED50=16.3 mg/kg).