223920-46-5Relevant articles and documents
Ultra-short acting neuromuscular blocking agents; di- and tri-substituted benzyl bisquaternary ammonium derivatives of bis(tropan-3α-ol)-diesters
Gyermek, Laszlo,Lee, Chingmuh,Cho, Young-Moon,Nguyen, Nguyen,Tsai, Shen-Kou
, p. 116 - 136 (2007/10/03)
Based on previous experiences with bisquaternary ammonium derivatives of bistropine esters of dicarboxylic acids we designed, synthesized and pharmacologically evaluated seventy dicarboxylic acid esters of tropine (tropan-3α-ol) bearing substituted N-benzyl quaternizing groups. Many of the quaternary derivatives of these bistropine diesters showed high neuromuscular blocking potency, very short onset and ultrashort or short duration of action in experimental animals.