124254-92-8

Basic information

• Product Name: 4-(bromomethyl)-1,2-phenylene diacetate
• Synonyms: 4-(bromomethyl)-1,2-phenylene diacetate
• CAS NO: 124254-92-8
• Molecular Weight: 287.11
• Mol File: 124254-92-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(bromomethyl)-1,2-phenylene diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(bromomethyl)-1,2-phenylene diacetate(124254-92-8)
• EPA Substance Registry System: 4-(bromomethyl)-1,2-phenylene diacetate(124254-92-8)

Safety Data

• Hazardous Substances Data: 124254-92-8(Hazardous Substances Data)

Upstream product

• 13287-30-4 4-methyl-1,2-phenylene diacetate 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 67727-64-4 3,4-diacetoxybenzaldehyde 
• 113118-24-4 acetic acid 2-acetoxy-4-hydroxymethyl-phenyl ester 

Downstream Products

• 223920-46-5 C₄₃H₅₆N₂O₁₂⁽²⁺⁾*2Br^(1-) 

Relevant articles and documents

Evaluating prodrug strategies for esterase-triggered release of alcohols

Prodrugs are effective tools in overcoming drawbacks typically associated with drug formulation and delivery. Those employing esterase-triggered functional groups are frequently utilized to mask polar carboxylic acids and phenols, increasing drug-like properties such as lipophilicity. Herein we detail a comprehensive assessment for strategies that effectively release hydroxy and phenolic moieties in the presence of an esterase. Matrix metalloproteinases (MMPs) serve as our proof-of-concept target. Three distinct ester-responsive protecting groups are incorporated into MMP proinhibitors containing hydroxy moieties. Analytical evaluation of the proinhibitors demonstrates that the use of a benzyl ether group appended to the esterase trigger leads to considerably faster kinetics of conversion and enhanced aqueous stability when compared with more conventional approaches where the trigger is directly attached to the inhibitor. Biological assays confirm that all protecting groups effectively cleave in the presence of esterase to generate the active inhibitor. The superior reaction-based prodrug strategies presented here should serve as a platform for esterase-responsive prodrug design in the future.

Ultra-short acting neuromuscular blocking agents; di- and tri-substituted benzyl bisquaternary ammonium derivatives of bis(tropan-3α-ol)-diesters

Based on previous experiences with bisquaternary ammonium derivatives of bistropine esters of dicarboxylic acids we designed, synthesized and pharmacologically evaluated seventy dicarboxylic acid esters of tropine (tropan-3α-ol) bearing substituted N-benzyl quaternizing groups. Many of the quaternary derivatives of these bistropine diesters showed high neuromuscular blocking potency, very short onset and ultrashort or short duration of action in experimental animals.