113118-88-0

Basic information

• Product Name: 1(4H)-Pyridinecarboxylic acid, 3-methoxy-4-methyl-, phenyl ester
• CAS NO: 113118-88-0
• Molecular Formula: C14H15NO3
• Mol File: 113118-88-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1(4H)-Pyridinecarboxylic acid, 3-methoxy-4-methyl-, phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1(4H)-Pyridinecarboxylic acid, 3-methoxy-4-methyl-, phenyl ester(113118-88-0)
• EPA Substance Registry System: 1(4H)-Pyridinecarboxylic acid, 3-methoxy-4-methyl-, phenyl ester(113118-88-0)

Safety Data

• Hazardous Substances Data: 113118-88-0(Hazardous Substances Data)

Upstream product

• 7295-76-3 3-methoxypyridine 
• 676-58-4 methylmagnesium chloride 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 113118-86-8 5-Methoxy-4-methyl-3-pyridinecarboxaldehyde 
• 113118-80-2 3-Formyl-5-methoxy-4-methyl-4H-pyridine-1-carboxylic acid phenyl ester 

Relevant articles and documents

Regioselective α-Lithiation of Unsymmetrical 1-(tert-Butoxycarbonyl)-1,4-dihydropyridines

The α-lithiation-methylation of unsymmetrical C-3-substituted 1-(tert-butoxycarbonyl)-1,4-dihydropyridines was studies.The yield and regioselectivity, C-2 vs C-6, of the metalation was dependent upon the C-3 substituent, the metalation base, and the reaction conditions.When the C-3 substituent was a methyl or methoxy group, and mesityllithium was the base, C-6 lithiation-methylation occurred predominately.With a strongly ortho-directing C-3 substituent , i.e., Cl, Br, OCONEt2, metalation with phenyllithium occurred mainly at C-2.An α-amino alkoxide function at C-3 acted only as a blocking group, forcing lithiation to occur mainly at C-6.Two new trisubstituted pyridines, 3--2,4-dimethylpyridine and 2,4-dimethyl-3-pyridinecarboxaldehyde, were prepared by aromatization of regioselectively alkylated 1,4-dihydropyridine intermadiates with o-chloranil or sulfur in refluxing decalin, demonstrating a new approach to pyridine substitution.