1131567-75-3

Basic information

• Product Name: C₂₂H₂₂FN₃OS
• Synonyms: C₂₂H₂₂FN₃OS
• CAS NO: 1131567-75-3
• Molecular Weight: 395.501
• Mol File: 1131567-75-3.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₂FN₃OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₂FN₃OS(1131567-75-3)
• EPA Substance Registry System: C₂₂H₂₂FN₃OS(1131567-75-3)

Safety Data

• Hazardous Substances Data: 1131567-75-3(Hazardous Substances Data)

Upstream product

• 870709-87-8 2-[(S)-1-(4-fluorophenyl)ethylamino]-5-methylthiazol-4(5H)-one 
• 101184-73-0 2-(4-bromophenyl)-2-methylpropanenitrile 

Downstream Products

• 1092660-08-6 2-(4-{2-[(S)-1-(4-fluorophenyl)ethylamino]-5-methyl-4-oxo-4,5-dihydrothiazol-5-yl}phenyl)-2-methylpropanamide 

Relevant articles and documents

Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11β-hydroxysteroid dehydrogenase type 1 inhibitors: Reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model

A series of compounds containing the 2-amino-1,3-thiazol-4(5H)-one core were found to be potent inhibitors of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). One of our lead compounds from this series activated the human nuclear xenobiotic