113163-19-2Relevant articles and documents
Organobis(cuprates): A New Class of Reagents and Method for Spiroannelation
Wender, Paul A.,White, Alan W.
, p. 2218 - 2223 (1988)
A one-step spiroannelation method applicable to the synthesis of the commonly encountered spirocyclic systems is described.The method involves the reaction of 3-halocycloalk-2-enones with a new type of cuprate reagent prepared from organodilithium reagents and copper thiophenoxide and is shown to provide efficient access to mspirononanes, spirodecanes, and spiroundecanes.The effects of temperature, concentration, and halogen variations on the efficiency of this process are reported for the reactions of 3-halo-5,5-dimethylcyclohex-2-enones 2a-c with 1,4-bis(CuSPhLi)butane (3).Under optimal conditions, chloroenone 2a reacts with reagent 3 to provide 9,9-dimethylspirodecan-7-one (5) in 96percent yield.The optimized conditions are found to apply generally to variously substituted halocyclopentenones and halocyclohexenones, providing the corresponding spirocyclic products in 76-93percent yield.The preparation of new dilithium reagents is also described along with their use in the spiroannelation procedure.The stability of the organobis(cuprates) is found to be influenced by the hybridization of the metal-bearing centers, with alkyl reagents more stable than alkenyl reagents.
Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D 3 analogues with aromatic side chains attached at C-17
Liu, Chao,Zhao, Guo-Dong,Mao, Xinliang,Suenaga, Tsutomu,Fujishima, Toshie,Zhang, Cheng-Mei,Liu, Zhao-Peng
, p. 569 - 575 (2014/11/07)
Two new analogues of the steroid hormone 1α,25-dihydroxyvitamin D3 with aromatic side chains attached at C-17 were designed to investigate their effects on VDR, HL-60 cell differentiation and tumor cell proliferation. These analogues were prepared by the classical photochemical ring opening approach. After the protection of both the 1α- and 3β-hydroxyl in 1α-hydroxydehydroepiandrosterone with TBS groups, followed by bromination with NBS and debromination in the presence of γ-collidine, the diene intermediate was obtained. Hydrazone formation followed by iodine oxidation gave a vinyl iodide. The aromatic side chain at C-17 was introduced via the Negishi coupling of the resulting intermediate with an in situ generated zinc reagent with the substituted aryl bromide (CD-side chain) in the presence of catalytic amount of Pd(PPh3)4. After the removal of the TBDMS and MOM protective groups, followed by UV irradiation and the subsequent thermal reaction, the 1α,25-(OH) 2-D3 analogues with a substituted phenyl ring attached at C-17 to replace the C-20 and C-21 were prepared. In the VDR competitive binding assay, compounds 2 and 3 almost lost their binding ability, and were only 0.01% and 0.015% as potent as the 1α,25-dihydroxyvitamin D3. However, compounds 2 and 3 were as potent as 1α,25-(OH)2-D3 in inducing HL-60 cell differentiation at concentrations of 30, 100, 300, 1000 nM, respectively. Moreover, compounds 2 and 3 exhibited similar or better antiproliferative potency against MCF-7 human breast cancer cells, the IC 50 values for analogues 2, 3 and the natural hormone were 7.08, 7.56, and 12.5 μM, respectively.
DERIVATIVES OF 1-PHENYL-1,5-DIHYDRO-BENZO[B] [1.4]DIAZEPINE-2.4-DIONE AS INHIBITORS OF HIV REPLICATION
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Page/Page column 67, (2011/09/19)
Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.