113193-63-8

Upstream product

• 51-80-9 bis-(dimethylamino)methane 
• 654682-18-5 1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)ethanone 
• 108-24-7 acetic anhydride 

Downstream Products

• 817553-51-8 5-(2,4-dichlorophenyl)-6-(4-chlorophenyl)-2-methylpyridine-3-carboxylic acid ethyl ester 
• 817553-57-4 6-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-2-methoxymethylpyridine-3-carboxylic acid ethyl ester 
• 96223-59-5 1-[(4R,5S)-5-(4-Chloro-phenyl)-4-(2,4-dichloro-phenyl)-2-oxo-2λ⁴-[1,3,2]dioxathiolan-4-ylmethyl]-1H-[1,2,4]triazole 
• 96223-59-5 1-[(4R,5R)-5-(4-Chloro-phenyl)-4-(2,4-dichloro-phenyl)-2-oxo-2λ⁴-[1,3,2]dioxathiolan-4-ylmethyl]-1H-[1,2,4]triazole 
• 96223-41-5 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2-oxo-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3-dioxolane 
• 96223-41-5 4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2-oxo-4-<(1H-1,2,4-triazol-1-yl)methyl>1,3-dioxolane 
• 93363-60-1 (threo)-1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propylene glycol 
• 93363-60-1 (erythro)-1-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propylene glycol 
• 107679-88-9 1-[(4R,5S)-5-(4-Chloro-phenyl)-4-(2,4-dichloro-phenyl)-[1,3]dioxolan-4-ylmethyl]-1H-[1,2,4]triazole 
• 93363-59-8 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propan-1-one 
• 107659-25-6 1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-2-hydroxy-3-imidazol-1-yl-propan-1-one 
• 111299-34-4 (4-Chloro-phenyl)-[2-(2,4-dichloro-phenyl)-oxiranyl]-methanone 
• 98617-28-8 [2,4-dichloro-α-(1,2,4-triazolylmethyl)benzyl]-(4-chlorophenyl)-ketone 

Relevant academic research and scientific papers

PYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF

The invention relates to compounds of formula (I): Wherein Z, R3 to R9 are as described herein. The invention also relates to methods of preparation of compounds of formula (I) and intermediates thereof. The compounds of this invention are active at CB1 cannabinoid receptor site, and are therefore, useful as pharmaceutical agents in treating a variety of diseases caused by the effects of CB1 cannabinoid receptors.

DIPHENYLPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF

The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I): where: R1 represents hydrogen or a (C1-C 4)alkyl; R2 represents: a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1-C4)alkanoyl; NR10R11; a nonaromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4)alkyl; a nonaromatic (C11-C12) carbocycle unsubstituted or mono-or polysubstituted with (C1-C4) alkyl; a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4)alkyl; or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin- 1-yl group; the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.

CHEMICAL COMPOUNDS

Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11betaHSD1 are described

A CONVENIENT SYNTHESIS OF 1H-1,2,4-TRIAZOL-1-YL-PROPAN-3-ONE DERIVATIVES BY MODIFIED MANNICH REACTION

1H-1,2,4-Triazol-yl-propan-3-ones were synthesized regioselectively using a modified Mannich reaction.Reactions of enones and Mannich bases with imidazole are also described.