113200-69-4Relevant academic research and scientific papers
2-IMINOXETANES FROM KETENIMINE-ALDEHYDE CYCLOADDITIONS. PART 1: SYNTHESIS AND CONTROLLED RING OPENING OF 2-N-p-TOLYLIMINO-3,3-DIMETHYL-4-PHENYLOXETANE
Barbaro, Gaetano,Battaglia, Arturo,Giorgianni, Patrizia
, p. 2995 - 2998 (1987)
Regiospecific cycloaddition of benzaldehyde to dimethylketene - N-p-tolylimine, catalyzed by lanthanide shift reagents, afforded the corresponding 2-iminoxetane.Controlled ring opening showed the oxetane to be a versatile building block for the synthesis of the corresponding acyclic -aminoalcohol, β-keto and β-hydroxyamide.In addition isomerization produced the corresponding 2-azetidinone (β-lactam).
2-Iminooxetane Chemistry. 3. Synthesis of β-Hydroxy Amides
Barbaro, Gaetano,Battaglia, Arturo,Giorgianni, Patrizia
, p. 5128 - 5136 (2007/10/02)
β-Hydroxy amides were synthesized by hydrolysis of the corresponding 2-iminooxetanes, which were prepared in a very simple step by lanthanide-catalyzed cycloaddition of aldehydes to ketene imines.The stereochemical outcome of the hydrolysis, performed und
