113200-68-3

Upstream product

• 100-52-7 benzaldehyde 
• 18779-86-7 dimethylketene-N-p-tolylimine 

Downstream Products

• 74185-91-4 4-Phenyl-3,3-dimethyl-1-p-tolylazetidin-2-one 
• 113200-69-4 3-Hydroxy-2,2-dimethyl-3-phenyl-N-p-tolyl-propionamide 
• 113200-70-7 2,2-Dimethyl-3-oxo-3-phenyl-N-p-tolylpropionamide 
• 113200-71-8 3-N-p-tolylamino-1-phenylpropanol 

Relevant academic research and scientific papers

2-Iminooxetane Chemistry. 2. General Synthesis from Ketene Imine-Aldehyde Cycloadditions

2-Iminooxetanes, versatile synthons of highly functionalized γ-amino alcohols, β-keto amides, β-hydroxy amides, and β-lactams, are synthesized by regiospecific 2 + 2 cycloadditions of aldehydes to ketene imines in the presence of lanthanide shift reagents

2-IMINOXETANES FROM KETENIMINE-ALDEHYDE CYCLOADDITIONS. PART 1: SYNTHESIS AND CONTROLLED RING OPENING OF 2-N-p-TOLYLIMINO-3,3-DIMETHYL-4-PHENYLOXETANE

Regiospecific cycloaddition of benzaldehyde to dimethylketene - N-p-tolylimine, catalyzed by lanthanide shift reagents, afforded the corresponding 2-iminoxetane.Controlled ring opening showed the oxetane to be a versatile building block for the synthesis of the corresponding acyclic -aminoalcohol, β-keto and β-hydroxyamide.In addition isomerization produced the corresponding 2-azetidinone (β-lactam).