113247-68-0Relevant articles and documents
Studies on Conformationally Restricted, Disiloxane Bridged Analogues of the Enkephalins
Davies, John S.,Tremeer, E. John,Treadgold, Richard C.
, p. 1107 - 1116 (2007/10/02)
Solution-phase synthesis of protected 2, Ser5>- and 2, Ser5>-enkephalins, followed by treatment with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane i2Si(Cl)-O-Si(Cl)Pri2> in base have yielded cyclic bridged disiloxane analogues showing biological activity in an in vitro assay.Highfield (1)H n.m.r. studies augmented by n.O.e. difference spectroscopy, temperature dependence studies of the amide protons, and the use of computer graphics support the presence of a 2-->5 H-bonded β-bend conformation for the most biologically potent of the cyclic analogues.