113266-92-5

Upstream product

• 113266-90-3 m-(benzyloxycarbonyl)phenyl acetic acid 
• 113266-91-4 S-(p-methoxybenzyl)-L-cysteinyl-D-Valine benzhydryl ester 
• 121-91-5 isophthalic acid 
• 100-39-0 benzyl bromide 
• 113266-89-0 2,2,2-trichloroethyl-phenyl acetate 
• 67852-96-4 3-(benzyloxycarbonyl)benzoyl chloride 
• 113266-88-9 iso-phthalic acid monobenzyl ester 

Downstream Products

• 113296-03-0 m-carboxyphenylacetyl-L-cysteinyl-D-valine 

Relevant academic research and scientific papers

Enzymatic process for 3-substituted cephalosporins

6β-(3-Carboxyphenylacetylamino)-2α-substituted--2β-methylpenam-3-carboxylic acids and 6β-adipoylamino--2α-substituted-2β-methylpenam-3-carboxylic acids, wherein the α-substituent is C1-C3 alkyl, C1-C3 alkoxy, vinyl or allenyl, are converted by the enzyme deacetoxy-cephalosporin C synthetase to the 7β-(3-carboxyphenyl-acetylamino)-3-substituted-3-cephem-4-carboxylic acid and the 7β-adipoylamino-3-substituted-3-cephem-4-car-boxylic acid.

AN EFFICIENT SUBSTITUTE FOR THE α-AMINODIPOYL MOIETY OF δ-(L-α-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE IN THE ENZYMATIC SYNTHESIS OF PENICILLINS

meta-Carboxyphenylacetyl-L-cysteinyl-D-valine was shown to be a highly efficient substrate for Isopenicillin N Synthetase, with similar Michaelis constant and maximum velocity parameters to the natural substrate δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine.