D-Valine, N-[S-[(4-methoxyphenyl)methyl]-N-[[3-[(phenylmethoxy)carbonyl]phenyl] acetyl]-L-cysteinyl]-, diphenylmethyl ester

Base Information

Chemical Name:D-Valine, N-[S-[(4-methoxyphenyl)methyl]-N-[[3-[(phenylmethoxy)carbonyl]phenyl] acetyl]-L-cysteinyl]-, diphenylmethyl ester
CAS No.:113266-92-5
Molecular Formula:C45H46N2O7S
Molecular Weight:758.935
Hs Code.:
Mol file:113266-92-5.mol

Synonyms:

Suppliers and Price of D-Valine, N-[S-[(4-methoxyphenyl)methyl]-N-[[3-[(phenylmethoxy)carbonyl]phenyl] acetyl]-L-cysteinyl]-, diphenylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of D-Valine, N-[S-[(4-methoxyphenyl)methyl]-N-[[3-[(phenylmethoxy)carbonyl]phenyl] acetyl]-L-cysteinyl]-, diphenylmethyl ester

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of D-Valine, N-[S-[(4-methoxyphenyl)methyl]-N-[[3-[(phenylmethoxy)carbonyl]phenyl] acetyl]-L-cysteinyl]-, diphenylmethyl ester

There total 7 articles about D-Valine, N-[S-[(4-methoxyphenyl)methyl]-N-[[3-[(phenylmethoxy)carbonyl]phenyl] acetyl]-L-cysteinyl]-, diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 113266-90-3
m-(benzyloxycarbonyl)phenyl acetic acid

: 113266-91-4
S-(p-methoxybenzyl)-L-cysteinyl-D-Valine benzhydryl ester

: 113266-92-5
(m-benzyloxycarbonylphenyl acetyl)-(S-p-methoxybenzyl-L-cysteinyl)-(D-valine benzhydryl ester)

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; for 24h;
DOI:10.1016/S0040-4020(01)83463-3

Reference yield:

: 121-91-5
isophthalic acid

: 113266-92-5
(m-benzyloxycarbonylphenyl acetyl)-(S-p-methoxybenzyl-L-cysteinyl)-(D-valine benzhydryl ester)

Guidance literature:: Multi-step reaction with 5 steps

1: 21 percent / 1) KOH / dimethylformamide / 2 h / 100 °C

2: thionyl chloride / benzene / 1 h / 80 °C / Heating

4: 37 percent / Zn dust, 1 M aqueous potassium dihydrogen phosphate / tetrahydrofuran / 0.5 h / 20 °C

5: 84 percent / 1-ethoxycarbonyl-2-ethoxy-dihydroquinoline / CH₂Cl₂ / 24 h

With potassium hydroxide; potassium dihydrogenphosphate; thionyl chloride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)83463-3

Reference yield:

: 100-39-0
benzyl bromide

: 113266-92-5
(m-benzyloxycarbonylphenyl acetyl)-(S-p-methoxybenzyl-L-cysteinyl)-(D-valine benzhydryl ester)

Guidance literature:: Multi-step reaction with 5 steps

1: 21 percent / 1) KOH / dimethylformamide / 2 h / 100 °C

2: thionyl chloride / benzene / 1 h / 80 °C / Heating

4: 37 percent / Zn dust, 1 M aqueous potassium dihydrogen phosphate / tetrahydrofuran / 0.5 h / 20 °C

5: 84 percent / 1-ethoxycarbonyl-2-ethoxy-dihydroquinoline / CH₂Cl₂ / 24 h

With potassium hydroxide; potassium dihydrogenphosphate; thionyl chloride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)83463-3