113272-40-5

Basic information

• Product Name: Piperazine, 1-(bromoacetyl)-4-phenyl-
• CAS NO: 113272-40-5
• Molecular Formula: C12H15BrN2O
• Molecular Weight: 283.168
• Mol File: 113272-40-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(bromoacetyl)-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(bromoacetyl)-4-phenyl-(113272-40-5)
• EPA Substance Registry System: Piperazine, 1-(bromoacetyl)-4-phenyl-(113272-40-5)

Safety Data

• Hazardous Substances Data: 113272-40-5(Hazardous Substances Data)

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 79-08-3 bromoacetic acid 

Downstream Products

• 1611527-03-7 3-[2-(4-phenylpiperazin-1-yl)ethoxy]phenol 
• 1611527-02-6 1-{2-[3-(benzyloxy)phenoxy]ethyl}-4-phenylpiperazine 
• 1610999-45-5 3-[2-(4-phenylpiperazin-1-yl)ethoxy]phenol hydrochloride 
• 1610999-44-4 1-{2-[3-(benzyloxy)phenoxy]ethyl}-4-phenylpiperazine hydrochloride 
• 99013-72-6 methyl trans-3-hydroxy-7-methoxy-4-<2-oxo-2-(4-phenyl-1-piperazinyl)ethyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate 
• 99013-72-6 methyl cis-3-hydroxy-7-methoxy-4-<2-oxo-2-(4-phenyl-1-piperazinyl)ethyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate 
• 113272-91-6 methyl 5-(4-phenyl-1-piperazinyl)-2-(6-methoxy-1,4-benzoxathian-3-yl)pentanoate 
• 99014-08-1 methyl cis-3-hydroxy-7-methoxy-4-<2-(4-phenyl-1-piperazinyl)ethyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate 
• 99024-81-4 methyl 7-methoxy-3-oxo-4-[2-oxo-2-(4-phenylpiperazin-1-yl)-ethyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate 

Relevant articles and documents

Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents

A series of 4-hydroxycoumarin derivatives were designed and synthesized in order to find some more potent antibacterial drugs. Their antibacterial activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus were tested. These compounds showed good antibacterial activities against Gram-positive strains. Compound 4g represented the most potent antibacterial activity against Bacillus subtilis and S. aureus with MIC of 0.236, 0.355 μg/mL, respectively. What's more, it showed the most potent activity against SaFabI with IC50 of 0.57 μM. Molecular docking of 4g into S. aureus Enoyl-ACP-reductase active site were performed to determine the probable binding mode, while the QSAR model was built to check the previous work as well as to introduce new directions.