99024-81-4

Basic information

• Product Name: methyl 7-methoxy-3-oxo-4-[2-oxo-2-(4-phenylpiperazin-1-yl)-ethyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate
• Synonyms: methyl 7-methoxy-3-oxo-4-[2-oxo-2-(4-phenylpiperazin-1-yl)-ethyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate
• CAS NO: 99024-81-4
• Molecular Weight: 470.546
• Mol File: 99024-81-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 7-methoxy-3-oxo-4-[2-oxo-2-(4-phenylpiperazin-1-yl)-ethyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 7-methoxy-3-oxo-4-[2-oxo-2-(4-phenylpiperazin-1-yl)-ethyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate(99024-81-4)
• EPA Substance Registry System: methyl 7-methoxy-3-oxo-4-[2-oxo-2-(4-phenylpiperazin-1-yl)-ethyl]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate(99024-81-4)

Safety Data

• Hazardous Substances Data: 99024-81-4(Hazardous Substances Data)

Upstream product

• 14761-39-8 1-(chloroacetyl)-4-phenylpiperazine 
• 99013-55-5 methyl 7-methoxy-3-oxo-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate 
• 113272-40-5 2-bromo-1-(4-phenylpiperazin-1-yl)ethanone 

Downstream Products

• 113272-91-6 methyl 5-(4-phenyl-1-piperazinyl)-2-(6-methoxy-1,4-benzoxathian-3-yl)pentanoate 
• 99014-08-1 methyl cis-3-hydroxy-7-methoxy-4-<2-(4-phenyl-1-piperazinyl)ethyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate 
• 99014-12-7 trans-7-methoxy-4-<3-(4-phenyl-1-piperazinyl)propyl>-3,4-dihydro-2H-1,5-benzoxathiepin-3-ol hydrochloride 
• 99013-72-6 methyl cis-3-hydroxy-7-methoxy-4-<2-oxo-2-(4-phenyl-1-piperazinyl)ethyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate 
• 99013-72-6 methyl trans-3-hydroxy-7-methoxy-4-<2-oxo-2-(4-phenyl-1-piperazinyl)ethyl>-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate 

Relevant articles and documents

1,5-benzoxathiepin derivatives, their production and use

Novel 1,5-benzoxathiepin derivatives of the formula: STR1 [wherein R1 and R2 are independently hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; R3 and R4 are independently hydrogen, optionally substituted lower alkyl or optionally substituted cycloalkyl or optionally substituted aralkyl, or both jointly form an optionally substituted ring together with the adjacent nitrogen atom; X is hydrogen, optionally substituted lower alkyl, optionally substituted aryl or a carboxyl group which may be esterified or amidated; Y is STR2 (wherein R5 is hydrogen, acyl or optionally substituted carbamoyl); m is an integer of 0 to 2; n is an integer of 1 to 6] and salts thereof exhibit serotonin S2 receptor blocking activity, calcium antagonism, actions to relieve cerebral vasospasm and to improve renal circulation and diuretic and antithrombotic activities, and are of value as a prophylactic and therapeutic agent for ischemic cardiopathies, thrombosis, hypertension and cerebral circulatory disorders.