113276-94-1 Usage
Description
The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 μM, respectively.
Chemical Properties
white to off-white crystalline solid
Uses
Active inhibitor of cyclic-nucleotide-dependent protein kinases.
Biochem/physiol Actions
cAMP and cGMP-dependent protein kinase inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 113276-94-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,2,7 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 113276-94:
(8*1)+(7*1)+(6*3)+(5*2)+(4*7)+(3*6)+(2*9)+(1*4)=111
111 % 10 = 1
So 113276-94-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3/p+1
113276-94-1Relevant articles and documents
5-Isoquinolinesulfonamide derivatives. 1. Synthesis and vasodilatory activity of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide derivatives
Morikawa,Sone,Asano
, p. 42 - 46 (2007/10/02)
Two novel series of N-(2-guanidinoalkyl)-5-isoquinolinesulfonamides, 2 and 3, were prepared. Many of the compounds possessed vasodilatory activity when injected locally into the femoral artery of dogs. The most potent compound, 1-amidino-4-(5-isoquinolylsulfonyl)-1,4-perhydrodiazepine, 33, was comparable to diltiazem, which is used clinically as a vasodilator.
