113276-94-1

Usage

Uses

Used in Research Applications:
H-8 DIHYDROCHLORIDE is used as an active inhibitor of cyclic-nucleotide-dependent protein kinases for elucidating mechanisms of cellular regulation and signal transduction in various research studies.
Used in Pharmaceutical Industry:
H-8 DIHYDROCHLORIDE is used as a potent inhibitor of PKA and PKG in the development of drugs targeting specific signaling pathways related to various diseases.
Used in Biochemical Analysis:
H-8 DIHYDROCHLORIDE is used as a biochemical tool to study the effects of inhibiting specific protein kinases on cellular processes and to gain insights into the role of these kinases in various biological functions.

Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

InChI:InChI=1/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3/p+1

Upstream product

• 129305-12-0 Toluene-4-sulfonic acid 2-(isoquinoline-5-sulfonylamino)-ethyl ester 
• 74-89-5 methylamine 
• 116700-33-5 N-(2-hydroxyethyl)-5-isoquinolinesulfonamide 
• 84468-15-5 5-isoquinolinesulfonyl chloride 

Relevant academic research and scientific papers

5-Isoquinolinesulfonamide derivatives. 1. Synthesis and vasodilatory activity of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide derivatives

Two novel series of N-(2-guanidinoalkyl)-5-isoquinolinesulfonamides, 2 and 3, were prepared. Many of the compounds possessed vasodilatory activity when injected locally into the femoral artery of dogs. The most potent compound, 1-amidino-4-(5-isoquinolylsulfonyl)-1,4-perhydrodiazepine, 33, was comparable to diltiazem, which is used clinically as a vasodilator.

Isoquinolinesulfonyl derivatives and process for the preparation thereof

A 5-isoquinolinesulfonyl derivative of Formula (I): STR1 wherein l is zero or one; m and n each is an integer of one to nine; m+n is an integer of at least one; R1 is a hydrogen atom, a C1-10 alkyl group, a C5-6 cycloalkyl group or an aryl group; or R2 and R3 each is a hydrogen atom, a C1-10 alkyl group, a C5-6 cycloalkyl group, an aryl group or an aralkyl group; R2 and R3 are C1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; or the STR2 group is a STR3 group wherein R4 and R5 each is a hydrogen atom, a C1-10 alkyl group, an aryl group or an aralkyl group and R6 is a hydrogen atom, a C1-10 alkyl group, and aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a STR4 group wherein R7 is a C1-8 alkyl group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.