1132817-32-3Relevant articles and documents
An efficient and scalable synthesis of the spirocyclic glycine transporter inhibitor GSK2137305
Graham, Jonathan P.,Langlade, Nathalie,Northall, John M.,Roberts, Alastair J.,Whitehead, Andrew J.
, p. 44 - 48 (2011/09/15)
An efficient and scalable synthesis of a glycine transporter inhibitor is presented. The key steps in the synthetic sequence are the formation of a spirocyclic imidazolidinone from an -amino nitrile and a cyclic ketone and an arylation of 4-methyl imidazo
SPIRO-CONDENSED IMIDAZOLONE DERIVATIVES INHIBITING THE GLYCINE TRANSPORTER
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Page/Page column 53-54, (2009/04/25)
Compounds of formula (I) and salts thereof are provided: formula (I), wherein the groups are as defined in the specification. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.