1132939-83-3Relevant academic research and scientific papers
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability
Randolph, John T.,Krueger, A. Chris,Donner, Pamela L.,Pratt, John K.,Liu, Dachun,Motter, Christopher E.,Rockway, Todd W.,Tufano, Michael D.,Wagner, Rolf,Lim, Hock B.,Beyer, Jill M.,Mondal, Rubina,Panchal, Neeta S.,Colletti, Lynn,Liu, Yaya,Koev, Gennadiy,Kati, Warren M.,Hernandez, Lisa E.,Beno, David W. A.,Longenecker, Kenton L.,Stewart, Kent D.,Dumas, Emily O.,Molla, Akhteruzzaman,Maring, Clarence J.
, p. 1153 - 1163 (2018/02/17)
ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the treatment of HCV infection. This compound was identified during a medicinal chemistry effort to impr
URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C
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Page/Page column 360, (2009/04/25)
Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.
