1132941-00-4

Basic information

• Product Name: 3-tert-butyl-2-methoxy-5-nitrobenzoate
• Synonyms: 3-tert-butyl-2-methoxy-5-nitrobenzoate
• CAS NO: 1132941-00-4
• Molecular Weight: 267.282
• Mol File: 1132941-00-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-tert-butyl-2-methoxy-5-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tert-butyl-2-methoxy-5-nitrobenzoate(1132941-00-4)
• EPA Substance Registry System: 3-tert-butyl-2-methoxy-5-nitrobenzoate(1132941-00-4)

Safety Data

• Hazardous Substances Data: 1132941-00-4(Hazardous Substances Data)

Upstream product

• 15018-03-8 methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 372137-83-2 methyl 3-tert-butyl-2-hydroxy-5-nitrobenzoate 

Downstream Products

• 1132941-02-6 methyl 5-amino-3-tert-butyl-2-methoxybenzoate 
• 1132937-18-8 (E)-N-(4-(1-(3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)prop-1-en-2-yl)phenyl)methanesulfonamide 
• 1132941-06-0 methyl 3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzoate 
• 1132942-16-5 methyl 3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzoate 
• 1132941-10-6 3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde 
• 1132942-20-1 3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde 
• 1132936-00-5 (E)-N-(4-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide 
• 1132941-16-2 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid 
• 1132936-01-6 (E)-N-(4-(3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide 
• 1132936-92-5 (E)-N-(4-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)-2-fluorophenyl)methanesulfonamidede 
• 1132941-85-5 3-(3-tert-butyl-4-methoxy-5-(methoxycarbonyl)phenylamino)propanoic acid 
• 1132941-14-0 methyl 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoate 
• 1132935-83-1 3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-methyl-N-(4-(methylsulfonamido)phenyl)benzamide 
• 1132945-26-6 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride 

Relevant articles and documents

High potency improvements to weak aryl uracil HCV polymerase inhibitor leads

Described herein is the development of a potent non-nucleoside, small molecule inhibitor of genotype 1 HCV NS5B Polymerase. A 23 μM inhibitor that was active against HCV polymerase was further elaborated into a potent single-digit nanomolar inhibitor of HCV NS5B polymerase by additional manipulation of the R and R1 substituents. Subsequent modifications to improve physical properties were made in an attempt to achieve an acceptable pharmacokinetic profile.

URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C

Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such interm