1132988-93-2Relevant articles and documents
Total synthesis and metabolic stability of hispidulin and its d-labelled derivative
Chen, Liang-Chieh,Hsu, Kai-Cheng,Chiou, Lih-Chu,Tseng, Hui-Ju,Huang, Wei-Jan
, (2017)
Hispidulin is a naturally occurring flavone known to have various Central nervous system (CNS) activities. Proposed synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall yields. To solve these problems, this study developed a novel scheme for synthesizing hispidulin, which had an improved overall yield as well as more concise reaction steps compared to previous methods reported. Additionally, using the same synthetic strategy, d-labelled hispidulin was synthesized to investigate its metabolic stability against human liver microsome. This work may produce new chemical entities for enriching the library of hispidulin-derived compounds.
Deuterated imidazole and thiadiazole derivatives and their medical use (by machine translation)
-
, (2019/10/07)
The invention of formula (I) indicated by the deuterated imidazole and thiadiazole derivative, or its pharmaceutically acceptable salt or esters or solvates. The compounds of this invention can be used for preparing the prevention or treatment of the thromboembolism drug. (by machine translation)
Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds
Dong, Yi,Du, Nana,Li, Xueyuan,Zheng, Litao,Liu, Gang
, p. 4110 - 4113 (2015/09/01)
A palladium-catalyzed tandem reaction is reported that involves chloropalladation/cyclization and dearomative cyclization to construct a tricyclic bridged [3.2.1] carbocyclic-skeleton and oxa- and aza-skeletons. In this domino process, a level of ring strain and other competitive reactions, i.e., protonolysis, β-hydride elimination, and chlorination of the C-Pd bond, were suppressed to the lowest level under mild reaction conditions.