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113299-38-0

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113299-38-0 Usage

Description

(S)-BICALUTAMIDE, also known as the (S)-enantiomer of Bicalutamide, is an off-white crystalline solid with antiandrogen and antineoplastic (hormonal) properties. It is a chiral compound that selectively targets androgen receptors, playing a crucial role in the treatment of prostate cancer and other androgen-dependent conditions.
Used in Pharmaceutical Industry:
(S)-BICALUTAMIDE is used as an antiandrogen for the treatment of prostate cancer. It works by blocking the effects of androgens, such as testosterone, which are responsible for the growth and progression of prostate cancer cells. This selective androgen receptor antagonist helps in reducing the size of the tumor and alleviating symptoms associated with advanced prostate cancer.
Additionally, (S)-BICALUTAMIDE is used as a hormonal antineoplastic agent in the treatment of other androgen-dependent conditions. Its ability to inhibit androgen action makes it a valuable therapeutic option for managing hormone-sensitive tumors and related disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 113299-38-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,2,9 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 113299-38:
(8*1)+(7*1)+(6*3)+(5*2)+(4*9)+(3*9)+(2*3)+(1*8)=120
120 % 10 = 0
So 113299-38-0 is a valid CAS Registry Number.

113299-38-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-BICALUTAMIDE

1.2 Other means of identification

Product number -
Other names R-bicalutamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113299-38-0 SDS

113299-38-0Relevant articles and documents

Separation of racemic bicalutamide by an optimized combination of continuous chromatography and selective crystallization

Kaemmerer, Henning,Horvath, Zoltan,Lee, Ju Weon,Kaspereit, Malte,Arnell, Robert,Hedberg, Martin,Herschend, Bjoern,Jones, Matthew J.,Larson, Kerstin,Lorenz, Heike,Seidel-Morgensten, Andreas

, p. 331 - 342 (2012)

A racemic mixture of bicalutamide, a drug substance used in the treatment of prostate cancer, was separated by simulated moving bed chromatography, with the objective of maximizing throughput at reduced outlet purity. The enriched extract stream was purified further by a crystallization process exploiting a shift in the eutectic composition. The optimal purity in between both process steps was identified. The separation scheme developed was validated on a scale of 600 g, and the results were compared to those of state-of-the art and discussed. The investigated scheme revealed a wide range of promising coupling conditions while showing superior productivities and enhanced process robustness.

Meta -Non-flat substituents: A novel molecular design to improve aqueous solubility in small molecule drug discovery

Ichikawa, Yuki,Hiramatsu, Michiaki,Mita, Yusuke,Makishima, Makoto,Matsumoto, Yotaro,Masumoto, Yui,Muranaka, Atsuya,Uchiyama, Masanobu,Hashimoto, Yuichi,Ishikawa, Minoru

supporting information, p. 446 - 456 (2021/01/29)

Aqueous solubility is a key requirement for small-molecule drug candidates. Here, we investigated the regioisomer-physicochemical property relationships of disubstituted benzenes. We found that meta-isomers bearing non-flat substituents tend to possess the lowest melting point and the highest thermodynamic aqueous solubility among the regioisomers. The examination of pharmaceutical compounds containing a disubstituted benzene moiety supported the idea that the introduction of a non-flat substituent at the meta position of a benzene substructure would be a promising approach for medicinal chemists aiming to improve the thermodynamic aqueous solubility of drug candidates, even though it might not be universally effective. This journal is

Catalytic Decarboxylative Radical Sulfonylation

Chen, Guangle,Chen, Jia-Rong,He, Jiayan,Li, Chaozhong,Li, Yi,Liu, Feng,Xiao, Wen-Jing,Zhang, Benxiang

, p. 1149 - 1159 (2020/05/13)

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