113308-97-7Relevant academic research and scientific papers
Coordination-Driven Folding in Multi-ZnII-Porphyrin Arrays Constructed on a Pillar[5]arene Scaffold
Trinh, Thi Minh Nguyet,Nierengarten, Iwona,Ben Aziza, Haifa,Meichsner, Eric,Holler, Michel,Chessé, Matthieu,Abidi, Rym,Bijani, Christian,Coppel, Yannick,Maisonhaute, Emmanuel,Delavaux-Nicot, Béatrice,Nierengarten, Jean-Fran?ois
, p. 11011 - 11021 (2017)
Pillar[5]arene derivatives bearing peripheral porphyrin subunits have been efficiently prepared from a deca-azide pillar[5]arene building block (17) and ZnII-porphyrin derivatives bearing a terminal alkyne function (9 and 16). For the resulting deca-ZnII-porphyrin arrays (18 and 20), variable temperature NMR studies revealed an intramolecular complexation of the peripheral ZnII-porphyrin moieties by 1,2,3-triazole subunits. As a result, the molecules adopt a folded conformation. This was further confirmed by UV/Vis spectroscopy and cyclic voltammetry. In addition, we have also demonstrated that the coordination-driven unfolding of 18 and 20 can be controlled by an external chemical stimulus. Specifically, addition of an imidazole derivative (22) to solution of 18 or 20 breaks the intramolecular coordination at the origin of the folding. The resulting molecular motions triggered by the addition of the imidazole ligand mimic the blooming of a flower.
N-Alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 8. The scope of tandem reactions involving hydroxylamine-alkyne cyclisations
Davison, Edwin C.,Forbes, Ian T.,Holmes, Andrew B.,Warner, Jacqueline A.
, p. 11601 - 11624 (1996)
A tandem sequence of hydroxylamine-alkyne cyclisation/1,3-dipolar cycloaddition, provides useful entry into tricyclic systems of type 4. The scope of such reactions is explored in this paper. A novel cascade cyclisation of N-hydroxypyrrolidines of type 26 and 28 involving hydroxylamine-alkyne cyclisation, Cope elimination and 1,3-dipolar cycloaddition is also reported.
Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models
Kamakolanu, Uma Gayathri,Meyer, Michael E.,Yasuda, Dennis,Polgar, Willma E.,Marti, Matteo,Mercatelli, Daniela,Pisanò, Clarissa Anna,Brugnoli, Alberto,Morari, Michele,Zaveri, Nurulain T.
, p. 2688 - 2704 (2020/03/31)
A novel series of C(3)-substituted piperdinylindoles were developed as nociceptin opioid receptor (NOP) partial agonists to explore a pharmacological hypothesis that NOP partial agonists would afford a dual pharmacological action of attenuating Parkinson'
SEQUENTIAL CLAISEN-ENE APPROACH TO CARBOCYCLIZATION: A NEW ENTRY TO A STEROID C/D RING SYNTHON
Takahashi, Kazuhiko,Mikami, Koichi,Nakai, Takeshi
, p. 5277 - 5280 (2007/10/02)
A new and facile entry to a steroid C/D ring synthon is described which relies on the sequential combination of the Claisen rearrangement with the intramolecular ene reaction involving an acetylenic bond with methoxycarbonyl group as the enophile.
Studies on Synthesis of Linear Aliphatic Compounds. Part 2. The Realisation of a Strategy for Repeated Molecular Doubling.
Igner, Eva,Paynter, Oliver I.,Simmonds, Derek J.,Whiting, Mark C.
, p. 2447 - 2454 (2007/10/02)
Routes from C11 and C12 starting-materials, obtainable free from near homologues, to compounds of doubled chain length have been explored as approaches to the synthesis of n-paraffins and of terminally mono- or bi-functional derivatives.Acetylene alkylation routes lead to problems with prtotecting groups, but the use of the Wittig reaction provides a method of molecular doubling convenient for repeated use, with formation of chain-lengths rising in a geometrical progression.The general problems inherent in the synthesis of very long-chain paraffins are discussed, earlier work is reviewed, and criteria for success are suggested.A useful protecting group for hydroxyl, the tri-p-tolylmethyl(trimtyl) ether, is described.
