1133158-43-6

Basic information

• Product Name: 6-chloro-2-(4'-methoxyphenyl)-2,3-dihydro-4(1H)-quinolone
• Synonyms: 6-chloro-2-(4'-methoxyphenyl)-2,3-dihydro-4(1H)-quinolone
• CAS NO: 1133158-43-6
• Molecular Weight: 287.746
• Mol File: 1133158-43-6.mol

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-(4'-methoxyphenyl)-2,3-dihydro-4(1H)-quinolone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(4'-methoxyphenyl)-2,3-dihydro-4(1H)-quinolone(1133158-43-6)
• EPA Substance Registry System: 6-chloro-2-(4'-methoxyphenyl)-2,3-dihydro-4(1H)-quinolone(1133158-43-6)

Safety Data

• Hazardous Substances Data: 1133158-43-6(Hazardous Substances Data)

Upstream product

• 144709-08-0 2-(4-methoxyphenyl)-2,3-dihydroquinolin-4(1H)-one 
• 1685-19-4 2-amino-5-chloroacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Organometallic titanocene complex as highly efficient bifunctional catalyst for intramolecular Mannich reaction

Bifunctional catalysts bearing two catalytic sites, Lewis acidic organometallic titanocene and Br?nsted acidic COOH, have been assembled in situ from Cp2TiCl2 with carboxylic acid ligands, showing high catalytic activity over an intramolecular Mannich reaction towards synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-ones. The determination of the bifunctional catalyst Cp2Ti(C8H4NO6)2 was elucidated by single X-ray HR-MS and investigation of catalytic behavior. In particular, masking the Br?nsted acidic COOH catalytic site with dormant COOMe lowered the reaction yield greatly, indicating that two catalytic sites work together to maintain high catalytic efficiency.

2-aryl-2,3-dihydro-4(1H)-quinolinone semicarbazone compound and application thereof

The invention relates to the field of medicine technology, and a series of novel 2-aryl-2,3-dihydrogen-4(1H)-quinolinone semicarbazone derivatives (I) and pharmaceutically acceptable salts, solvates,optical isomers or polymorphs are designed and synthesized. The derivative (I) and its pharmaceutically acceptable salt, solvate, optical isomer or polymorph can be mixed as an active ingredient witha pharmaceutically acceptable carrier to prepare a pharmaceutical composition. A double dilution method is used for test of the antifungal activity of the derivative (I) and its pharmaceutically acceptable salt, solvate, optical isomer or polymorph, and the results show that the derivative has stronger killing effect on clinically common pathogenic fungi, and is expected to overcome the defects oflarge toxic and side effects, easy generation of drug resistance of azole antifungal medicines which are widely used clinically. The specific formula is shown in the description.

Facile iodine(III)-mediated approach for the regioselective chlorination of 2-aryl-2,3-dihydro-4(1H)-quinolones

Oxidation of 2-aryl-2,3-dihydro-4(1H)-quinolones (1) with 1.5 equivalents of (dichloroiodo)benzene in dichloromethane at room temperature leads to regioselective chlorination, thereby offering an efficient method for the synthesis of new 2-aryl-6-chloro-2