1685-19-4

Basic information

• Product Name: Ethanone,1-(2-amino-5-chlorophenyl)-
• Synonyms: Ethanone,1-(2-amino-5-chlorophenyl)-;1-(2-aMino-5-chlorophenyl)ethan-1-one;(2-AMino-5-chlorophenyl)ethanone
• CAS NO: 1685-19-4
• Molecular Formula: C8H8ClNO
• Molecular Weight: 169.61
• Mol File: 1685-19-4.mol
• Article Data: 26

Chemical Properties

• Melting Point: 65-66 °C
• Boiling Point: 305.14 °C at 760 mmHg
• Flash Point: 138.344 °C
• Appearance: /
• Density: 1.255 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.67±0.10(Predicted)
• CAS DataBase Reference: Ethanone,1-(2-amino-5-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,1-(2-amino-5-chlorophenyl)-(1685-19-4)
• EPA Substance Registry System: Ethanone,1-(2-amino-5-chlorophenyl)-(1685-19-4)

Safety Data

• Hazardous Substances Data: 1685-19-4(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-amino-5-chlorophenyl)-, also known as 5-chloro-2-aminophenyl ketone, is an organic compound with the molecular formula C8H8ClNO. It is a derivative of acetophenone, with a chlorine and an amino group attached to the phenyl ring. This chemical is used as an intermediate in the production of pharmaceuticals and agrochemicals, and it is also used as a building block in the synthesis of various organic compounds. It has been studied for its potential biological and pharmacological activities, including its anti-inflammatory and anti-cancer properties. Additionally, it is important to handle and store this chemical with proper safety precautions due to its potential health hazards.

InChI:InChI=1/C8H8ClNO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-4H,10H2,1H3

Upstream product

• 539-03-7 N-(4-chlorophenyl)acetamide 
• 106-47-8 4-chloro-aniline 
• 75-05-8 acetonitrile 
• 917-54-4 methyllithium 
• 635-21-2 5-chloroanthranilic acid 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 1438400-36-2 N-(2-acetyl-4-chlorophenyl)-4-methylbenzenesulfonamide 
• 75-16-1 methylmagnesium bromide 
• 150879-48-4 N-methyl-N-methyloxy-2-amino-5-chlorobenzamide 
• 99-02-5 3'-Chloroacetophenone 
• 18640-60-3 5-chloro-2-nitroacetophenone 

Downstream Products

• 21740-91-0 2-(2-amino-5-chloro-phenyl)-propan-2-ol 
• 18514-88-0 6-chloro-4(1H)-cinnoline 
• 41019-23-2 benzoic acid-(2-acetyl-4-chloro-anilide) 
• 130594-44-4 2-Amino-5-chloroacetophenone hydrazone 
• 139439-31-9 N-(2-Acetyl-4-chloro-phenyl)-2,2,2-trifluoro-acetamide 
• 326585-82-4 6-(2-acetyl-4-chloro-phenylamino)quinoline-5,8-dione 
• 937817-44-2 (2-acetyl-4-chlorophenylamino)acetic acid ethyl ester 
• 950818-64-1 C₁₄H₁₈ClON 
• 950818-68-5 C₁₄H₁₄ONC₂Cl 
• 720681-64-1 4-chloro-2-(prop-1-en-2-yl)aniline 

Relevant articles and documents

Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.

Copper-catalyzed tandem annulation/enol nucleophilic addition to access multisubstituted indoles

A method to access various multisubstituted indoles from propargylic alcohols and readily available enol nucleophiles by copper-catalyzed tandem annulation/enol nucleophilic addition has been developed. Compared to the expensive metal catalysts such as platinum, gold, silver, and palladium used previously, the most economical copper(i) catalyst could achieve this reaction efficiently. The fused heterocyclic compounds, pyrrolo[1,2-a] indoles, could be afforded by further transformation of the products. The allyl cation intermediate may be involved in the mechanism.